MAT1A

Alternative Names: EC 2.5.1.6, MAT, MAT 1, MAT1A, Methionine adenosyltransferase I/III, MAT-I/III, MATA1, SAMS, SAMS1, AdoMet synthase 1, AMS1, Methionine adenosyltransferase 1, S-adenosylmethionine synthase isoform type-1.

MAT1A is an enzyme that plays a crucial role in transferring the adenosyl moiety of ATP to methionine to form S-adenosylmethionine and tripolyphosphate. S-adenosylmethionine is responsible for providing methyl groups for various biological processes. Mutations in the MAT1A gene can lead to methionine adenosyltransferase deficiency. The expression of MAT1A is associated with a differentiated phenotype, while MAT2A expression is linked to a dedifferentiated phenotype and reduced AdoMet synthesis in liver cells. In human hepatocellular carcinoma, the switch from MAT1A to MAT2A expression by NFκB and TNFα promotes cancer cell growth.

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  • Sku: PSB-enz-493-2µg
  • Vendor: ProSpec-Tany
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Product Details

Product Description

Recombinant Human Methionine Adenosyltransferase I, Alpha is an enzyme that plays a key role in the synthesis of S-adenosylmethionine (SAMe) in the liver. Belonging to the adenosyltransferase family, this protein is responsible for catalyzing the transfer of an adenosyl group from ATP to L-methionine, forming SAMe. With a molecular weight of approximately 39 kDa, Recombinant Human Methionine Adenosyltransferase I, Alpha is crucial for maintaining proper methylation reactions in the body.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System E. coli
Purity 95% by SDS-PAGE
Activity
 Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 N/A
Structure Tetramer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Frozen
Formulation The MAT1A protein solution contains 20mM Tris-HCl pH-8, 1mM DTT, 100mM NaCl and 10% glycerol.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MGSSHHHHHS SGLVPRGSHM NGPVDGLCDH SLSEGVFMFT SESVGEGHPD KICDQISDAV LDAHLKQDPN AKVACETVCK TGMVLLCGEI TSMAMVDYQR VVRDTIKHIG YDDSAKGFDF KTCNVLVALE QQSPDIAQCV HLDRNEEDVG AGDQGLMFGY ATDETEECMP LTIILAHKLN ARMADLRRSG LLPWLRPDSK TQVTVQYMQD NGAVIPVRIH TIVISVQHNE DITLEEMRRA LKEQVIRAVV PAKYLDEDTV YHLQPSGRFV IGGPQGDAGV TGRKIIVDTY GGWGAHGGGA FSGKDYTKVD RSAAYAARWV AKSLVKAGLC RRVLVQVSYA IGVAEPLSIS IFTYGTSQKT ERELLDVVHK NFDLRPGVIV RDLDLKKPIY QKTACYGHFG RSEFPWEVPR KLVF.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution
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References

Not Available
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MAT1A
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