MAOB

Alternative Names: Monoamine oxidase type B, MAO-B, MAOB, Amine oxidase [flavin-containing] B, MGC26382.

MAO-B, a member of the flavin monoamine oxidase family, is a mitochondrial enzyme that plays a crucial role in metabolizing biogenic and xenobiotic monoamines such as catecholamines and serotonin. Found in platelets and DOPA-secreting neurons in the brain, MAO-B possesses a key function in the degradation of DOPA. It preferentially degrades benzylamine and phenylethylamine. The MAOB gene is associated with traits related to autism, empathy, and Asperger syndrome, as well as being linked to Alzheimer's disease. High levels of phenylethylamine in newborns due to decreased MAO B activity may indicate the presence of phenylketonuria. Certain genetic variations in MAO-B have been linked to smoking behavior.

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  • Sku: PSB-enz-440-2µg
  • Vendor: ProSpec-Tany
$60.00 USD
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Title

Product Details

Product Description

Recombinant Human Monoamine Oxidase B (MAO-B) is an enzyme that belongs to the family of monoamine oxidases, which are responsible for the metabolism of neurotransmitters such as dopamine and serotonin. MAO-B has a molecular weight of approximately 58 kDa and plays a role in the regulation of neurotransmitter levels in the brain. This enzyme is commonly used in research and drug development for its involvement in neurodegenerative diseases such as Parkinson's disease.

Current Lead Time

7-14 Days

Product Specifications

Species
Human
Expression System E. coli
Purity 95% by SDS-PAGE
Activity
Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
59.84 kDa
Structure Dimer
Endotoxin Concentration
Not Available
Purification Method Not Available
Form
Frozen
Formulation MAO-B protein is supplied in 20mM Tris-HCl, pH 8.0, 250mM NaCl, 1mM EDTA and 50% glycerol.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

Check Uniprot Link

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution

References

Not Available

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MAOB

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