maIL16

Alternative Names: IL16, Interleukin-16, LCF, Lymphocyte Chemoattractant Factor, prIL-16, FLJ16806, FLJ42735, FLJ44234, HsT19289.

IL-16 is a pleiotropic cytokine that has multiple functions including being a chemoattractant, a modulator of T cell activation, and an inhibitor of HIV replication. The CD4 receptor is responsible for mediating the signaling of IL-16. The proteolytic processing of the IL-16 gene results in the production of two functional proteins. The secreted C-terminal peptide is responsible for the exclusive functions of IL-16, while the N-terminal product may have a role in controlling the cell cycle. Caspase 3 is reported to be involved in the proteolytic processing of IL-16. Different isoforms of the IL-16 gene have been identified with two transcript variants. IL-16 promotes migration of CD4+ lymphocytes, monocytes, and eosinophils and also induces the expression of interleukin 2 receptor, which is a ligand for CD4 on T-lymphocytes.

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  • Sku: PSB-cyt-153-2µg
  • Vendor: ProSpec-Tany
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Safety Data Sheet
UniProt Listing
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Product Details

Product Description

Recombinant Rhesus Macaque Interleukin-16 is a protein that plays a significant role in immune response modulation. Belonging to the cytokine family, it acts as a chemotactic factor for various immune cells, including CD4+ T lymphocytes. With a molecular weight of approximately X kilodaltons, this protein exhibits chemotactic activity by binding to its receptor, CD4, and subsequently attracting immune cells to the site of inflammation. Understanding the properties and functions of Recombinant Rhesus Macaque Interleukin-16 contributes to the comprehension of immune system regulation and holds potential in therapeutic applications.

Current Lead Time

7-14 Days

Product Specifications

Species
 Macaque
Expression System E. coli
Purity 98% by SDS-PAGE
Activity
 Fully biologically active when compared to standard. Determined by its ability to chemoattract human CD4+ T-Lymphocytes using a concentration range of 50.0-100.0ng/ml corresponding to a Specific Activity of 10,000-20,000IU/mg. Fully biologically active when compared to standard. Determined by its ability to chemoattract human CD4+ T-Lymphocytes using a concentration range of 50.0-100.0ng/ml corresponding to a Specific Activity of 10,000-20,000IU/mg.
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 12.5 kDa
Structure Homodimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Lyophilized
Formulation Lyophilized from a 0.2?m filtered concentrated solution in PBS, pH 7.4.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

SAASASAASD VSVESSAEAT VYTVTLEKMS AGLGFSLEGG KGSLHGDKPL TINRIFKGAA SEQSETIQPG DEILQLAGTA MQGLTRFEAW NIIKALPDGP VTIVIRRKSL QPKETTAAAD S

Storage Instruction

Lyophilized IL-16 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution IL-16 should be stored at 4°C between 2-7 days and for future use below -18°C.Please prevent freeze-thaw cycles.

Sample Prep Instruction

It is recommended to reconstitute the lyophilized ;IL-16 in sterile 18M-cm H₂O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

References

Not Available
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maIL16
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