Leptin tA

Alternative Names: Not Available

Recombinant Human Leptin Triple Antagonist is a bioengineered protein designed to inhibit the activity of leptin, a hormone responsible for regulating energy balance and appetite. Belonging to the family of recombinant proteins, this antagonist is synthesized through genetic engineering techniques. With a molecular weight of approximately X kilodaltons, it exhibits a potent inhibitory effect on leptin signaling pathways, making it a promising therapeutic candidate for conditions related to dysregulated energy homeostasis.

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  • Sku: PSB-cyt-352-10µg
  • Vendor: ProSpec-Tany
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Title

Product Details

Product Description

Recombinant Human Leptin Triple Antagonist is a bioengineered protein designed to inhibit the activity of leptin, a hormone responsible for regulating energy balance and appetite. Belonging to the family of recombinant proteins, this antagonist is synthesized through genetic engineering techniques. With a molecular weight of approximately X kilodaltons, it exhibits a potent inhibitory effect on leptin signaling pathways, making it a promising therapeutic candidate for conditions related to dysregulated energy homeostasis.

Current Lead Time

7-14 Days

Product Specifications

Species
Human
Expression System E. coli
Purity 98% by SDS-PAGE
Activity
ProSpec’s Leptin triple antagonist is capable of inhibiting leptin-induced proliferation of BAF/3 cells stably transfected with the long form of human leptin receptor. It also inhibits various leptin effects in several in vitro bioassays. ProSpec’s Leptin triple antagonist is capable of inhibiting leptin-induced proliferation of BAF/3 cells stably transfected with the long form of human leptin receptor. It also inhibits various leptin effects in several in vitro bioassays.
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
N/A
Structure Homodimer
Endotoxin Concentration
Not Available
Purification Method Not Available
Form
Lyophilized
Formulation The protein was lyophilized from a concentrated (1mg/ml) solution with 0.0045mM NaHCO3.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

The sequence of the first five N-terminal amino acids was determined and was found to be Ala-Val-Pro-Ile-Gln.

Storage Instruction

Lyophilized Leptin Antagonist Triple Mutant Human Recombinant although stable at room temperature for several weeks, should be stored desiccated below -18° C. Upon reconstitution at > 0.1 mg/ml and up to 2 mg/ml and filter sterilization Leptin mutant can be stored at 4° C or even room temperature for several weeks making it suitable for long term infusion studies using osmotic pumps. At lower concentration addition of a carrier protein (0.1% HSA or BSA) is suggested. Please prevent freeze-thaw cycles.

Sample Prep Instruction

It is recommended to reconstitute the lyophilized Leptin Antagonist Triple Mutant Human Recombinant in sterile 0.4% NaHCO3, not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

References

Not Available

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Leptin tA

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