KRT18

Alternative Names: Keratin type I cytoskeletal 18, Cytokeratin-18, CK-18, Keratin-18, K18, KRT18, CYK18, Cell proliferation-inducing gene 46 protein.

KRT18 is responsible for producing keratin 18, which is a type I intermediate filament chain. Keratin 18, along with keratin 8, is highly prevalent in the intermediate filament gene family. Both proteins are found in single layer epithelial tissues in the body. Mutations in the KRT18 gene have been associated with cryptogenic cirrhosis. This gene has two transcript variants that encode the same protein.

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  • Sku: PSB-pro-349-5µg
  • Vendor: ProSpec-Tany
$60.00 USD
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Title

Product Details

Product Description

Recombinant Human Cytokeratin 18 is a protein that plays a significant role in maintaining the structural integrity of epithelial cells. Belonging to the cytokeratin family, this protein is involved in various cellular processes, including cell adhesion, migration, and signaling. With a molecular weight of approximately 45 kilodaltons, Recombinant Human Cytokeratin 18 serves as a crucial biomarker in the field of cancer research and diagnostics. Its precise quantification and detection provide valuable insights into epithelial cell abnormalities, aiding in the early detection and monitoring of cancer progression.

Current Lead Time

7-14 Days

Product Specifications

Species
Human
Expression System E. coli
Purity 95% by SDS-PAGE
Activity
Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
N/A
Structure Dimer
Endotoxin Concentration
Not Available
Purification Method Not Available
Form
Lyophilized
Formulation The protein (1mg/ml) was lyophilized from a sterile solution containing 30mM Tris-HCl pH-8, 9.5M urea, 2mM EDTA, 2mM DTT and 10mM methylammonium chloride.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

Check Uniprot Link

Storage Instruction

Lyophilized CK-18 although stable at room temperature for 3 weeks, should be stored between 2-8° C. Upon reconstitution CK-18 should be stored at 4° C between 2-7 days and for future use below -18° C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.

Sample Prep Instruction

It is recommended to reconstitute the lyophilized 1mg CK-18 in sterile 18MΩ-cm H₂O not less than 700µl, which can then be further diluted to other aqueous solutions. ;

References

Not Available

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KRT18

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