KMT5A

Alternative Names: KMT5A, PR-Set7, SET07, SET8, SETD8, H4-K20-HMTase KMT5A, KMT5A

KMT5A is an enzyme that catalyzes the methylation of histones and non-histone proteins, playing a role in maintaining the structure of DNA during cell division. It is involved in regulating gene expression and cell division in animals. Additionally, KMT5A helps prevent cellular senescence through controlling metabolic processes. KMT5A also plays a role in modifying p53/TP53, leading to the repression of certain target genes. The absence of KMT5A promotes nucleolar function and mitochondrial metabolism.

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  • Sku: PSB-enz-1080-2µg
  • Vendor: ProSpec-Tany
$60.00 USD
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Title

Product Details

Product Description

Recombinant Human Lysine Methyltransferase 5A is a member of the lysine methyltransferase family, responsible for catalyzing the transfer of methyl groups to lysine residues on histone proteins. This enzyme plays a role in regulating gene expression and chromatin structure. Recombinant Human Lysine Methyltransferase 5A has a molecular weight of approximately 160 kDa and is commonly used in research to study epigenetic modifications and their impact on cellular processes.

Current Lead Time

7-14 Days

Product Specifications

Species
Human
Expression System Sf9 - Baculovirus cells
Purity 85.0 % by SDS-PAGE
Activity
Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
18.9 kDa
Structure Dimer
Endotoxin Concentration
Not Available
Purification Method Not Available
Form
Frozen
Formulation KMT5A protein solution (0.25mg/ml) contains 20mM Tris-HCl buffer (pH8.0), 5mM DTT, 0.2M NaCl, 1mM EDTA and 50% glycerol.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MKAELQSEER KRIDELIESG KEEGMKIDLI DGKGRGVIAT KQFSRGDFVV EYHGDLIEIT DAKKREALYA QDPSTGCYMY YFQYLSKTYC VDATRETNRL GRLINHSKCG NCQTKLHDID GVPHLILIAS RDIAAGEELL YDYGDRSKAS IEAHPWLKHH HHHHH.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution

References

Not Available

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KMT5A

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