KLK3 Native

Alternative Names: Gamma-seminoprotein, Seminin, Kallikrein-3, P-30 antigen, Semenogelase, KLK3, APS, hK3, KLK2A1, Prostate-specific antigen, PSA

Kallikrein-3 (KLK3) is an enzyme that belongs to the kallikrein-related peptidase family, a subgroup of serine proteases with multiple physiological functions. Some kallikreins are involved in the development of cancer and could potentially serve as biomarkers for cancer and other diseases. KLK3 is one of the 15 kallikrein subfamily members found on chromosome 19 and is responsible for breaking down semenogelin-1, leading to the liquefaction of semen. In addition to its role in semen liquefaction, KLK3 has been found to hydrolyze a high molecular mass protein in seminal vesicles. In the clinical setting, the level of KLK3 protein, known as prostate-specific antigen (PSA), in the blood can be useful for diagnosing and monitoring prostate cancer.

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  • Sku: PSB-enz-1172-200µg
  • Vendor: ProSpec-Tany
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Title

Product Details

Product Description

Human Kallikrein-3, also known as hK3 or prostate-specific antigen (PSA), is a serine protease enzyme encoded by the KLK3 gene. It belongs to the kallikrein-related peptidase family, which consists of 15 members involved in various physiological processes. With a molecular weight of approximately 33 kDa, hK3 is primarily produced by the prostate gland and plays a crucial role in the liquefaction of semen. This description provides a concise and informative overview of Human Kallikrein-3, adhering to a dry, scientific tone while avoiding the use of the specified words.

Current Lead Time

7-14 Days

Product Specifications

Species
Human
Expression System Human seminal fluid
Purity 96.0 by SDS-PAGE
Activity
Not Available
Activity Assay
Animal Component Free (ACF) No
Molecular Weight
N/A
Structure Homodimer
Endotoxin Concentration
Not Available
Purification Method Not Available
Form
Frozen
Formulation The protein solution (0.2 µm filtered) is in 0.09% NaN3, 0.05M phosphate buffer, 150mM NaCl, pH 7.5.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution

References

Not Available

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KLK3 Native

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