KLK1 His

Alternative Names: KLK1, KLK-1, KLKR, KLK6, Tissue Kallikrein, hKLK1, EC 3.4.21.35, Kidney/pancreas/salivary gland kallikrein, Kallikrein-1, HK1, HK-1

Kallikreins, a group of serine protease enzymes, have various physiological functions and are being studied for their potential role as cancer biomarkers. One member of this enzyme family, KLK1, is located on chromosome 19 and is known to release the vasoactive peptide Lys-bradykinin. Human Kallikrein-1, also known as Kallidinogenase or Kininogenase, is found in saliva, pancreatic juices, and urine, where it catalyzes the proteolysis of bradykininogen to bradykinin. KLK1, derived from humans or pigs, has been used in the treatment of mild to moderate hypertension and cerebral blood vessel blockage. KLK1 has specific preferences at different binding sites and has been associated with hypertension in certain populations. Though KLK1 is not involved in the kallikrein-kinins pathway activation in carotid arteriosclerosis, it plays a role in maintaining circulation homeostasis and participates in epidermal desquamation.

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  • Sku: PSB-enz-690-2µg
  • Vendor: ProSpec-Tany
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UniProt Listing
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Product Details

Product Description

Recombinant Human Kallikrein-1, His Tag is a member of the kallikrein family of serine proteases. This protein plays a role in the regulation of blood pressure and inflammation by cleaving kininogen to release bradykinin. With a molecular weight of approximately 28 kDa, Recombinant Human Kallikrein-1, His Tag is commonly used in research studies to investigate its physiological functions and potential therapeutic applications.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System E. coli
Purity 90% by SDS-PAGE
Activity
 Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 28.7 kDa
Structure Dimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Frozen
Formulation The KLK1 solution (0.25mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 10% glycerol and 1mM DTT.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MGSSHHHHHH SSGLVPRGSH MIVGGWECEQ HSQPWQAALY HFSTFQCGGI LVHRQWVLTA AHCISDNYQL WLGRHNLFDD ENTAQFVHVS ESFPHPGFNM SLLENHTRQA DEDYSHDLML LRLTEPADTI TDAVKVVELP TQEPEVGSTC LASGWGSIEP ENFSFPDDLQ CVDLKILPND ECKKVHVQKV TDFMLCVGHL EGGKDTCVGD SGGPLMCDGV LQGVTSWGYV PCGTPNKPSV AVRVLSYVKW IEDTIAENS.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution
​

References

Not Available
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KLK1 His
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