k9SCF

Alternative Names: Kit ligand Precursor, C-kit ligand, SCF, Mast cell growth factor, MGF, SF, KL-1, Kitl, DKFZp686F2250.

Stem cell factor (SCF), also known as "steel factor" or "c-kit ligand," is a cytokine that binds to CD117 (c-Kit). It exists in two forms: cell surface bound SCF and soluble SCF. Soluble SCF is produced when surface-bound SCF is cleaved by metalloproteases. SCF is a growth factor that plays a crucial role in the survival, proliferation, and differentiation of hematopoietic stem cells and other progenitor cells. One of its functions is the transformation of BFU-E cells, the earliest erythrocyte precursors, into CFU-E cells in the erythrocytic series.

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  • Sku: PSB-cyt-194-2µg
  • Vendor: ProSpec-Tany
$60.00 USD
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Safety Data Sheet
UniProt Listing
NCBI Link

Product Details

Product Description

Recombinant Canine Stem Cell Factor (RCSCF) is a protein that belongs to the cytokine family. With a molecular weight of approximately 18-20 kDa, RCSCF plays a significant role in regulating the growth and differentiation of stem cells in canines. This protein acts as a potent stimulator for the proliferation and survival of hematopoietic stem cells, promoting their development into various blood cell lineages. By binding to its receptor, RCSCF initiates intracellular signaling cascades, ultimately influencing the fate and functionality of stem cells. Its precise and controlled action makes RCSCF a valuable tool in stem cell research and regenerative medicine applications for canines.

Current Lead Time

7-14 Days

Product Specifications

Species
 Canine
Expression System E. coli
Purity 97.0% by SDS-PAGE
Activity
 Fully biologically active when compared to standard. The ED50 as calculated by the dose-dependent stimulation of the proliferation of human TF-1 cells is less than 2.0ng/ml, corresponding to a specific activity of 5,000,000IU/mg. Fully biologically active when compared to standard. The ED50 as calculated by the dose-dependent stimulation of the proliferation of human TF-1 cells is less than 2.0ng/ml, corresponding to a specific activity of 5,000,000IU/mg.
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 18.4 kDa
Structure Homodimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Lyophilized
Formulation Lyophilized from a 0.2µm filtered concentrated solution in PBS, pH 7.4.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

KGICGKRVTD DVKDVTKLVA NLPKDYKIAL KYVPGMDVLP SHCWISVMVE QLSVSLTDLL DKFSNISEGL SNYSIIDKLV KIVDDLVECT EGYSFENVKK APKSPELRLF TPEEFFRIFN RSIDAFKDLE TVASKSSECV VSSTLSPDKD SRVSVTKPFM LPPVA

Storage Instruction

Lyophilized SCF although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution SCF should be stored at 4°C between 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.

Sample Prep Instruction

It is recommended to reconstitute the lyophilized Stem Cell Factor in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

References

Not Available
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k9SCF
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