IL17 A F

Alternative Names: IL17A/F, IL17AF, IL-17A/F, IL-17 AF, IL17 A/F, Interleukin-17 A/F, Interleukin-17 AF, IL-17 A/F

Human IL-17A/F is a 40kDa glycoprotein secreted as a disulfide-linked heterodimer that consists of two proteins from the IL-17 family, IL-17A and IL-17F. IL-17A and IL-17F, along with other proteins in the IL17 family, contain a cysteine knot motif with two disulfide-bonds. Human IL-17A is a precursor consisting of a 155 amino acid chain, including a 23 amino acid signal sequence and a 132 amino acid region with an N-linked glycosylation site. Similarly, Human IL-17F is a precursor comprising a 153 amino acid chain with a 20 amino acid signal sequence and a 133 amino acid region, also having an N-linked glycosylation site. Both IL-17A and IL-17F share 50% amino acid sequence identity. They also exhibit approximately 60% homology in their amino acid sequence to mouse IL-17A and IL-17F. The production of IL-17A/F and IL-17A, IL-17F homodimers is carried out by activated CD4+ T cells known as Th17 cells. IL-23 triggers Th17 cells to produce IL-17A/F. IL-17A/F binds to IL-17RA, and the interaction between IL-17RA and IL-17RC forms a heterodimer that allows the binding of IL

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  • Sku: PSB-cyt-623-2µg
  • Vendor: ProSpec-Tany
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Safety Data Sheet
UniProt Listing
NCBI Link

Product Details

Product Description

Recombinant Human Interleukin-17 A/F Heterodimer is a protein that belongs to the Interleukin-17 family. This heterodimeric cytokine consists of two subunits, Interleukin-17A and Interleukin-17F, which are covalently linked. With a molecular weight of approximately X kDa, this protein plays a significant role in immune responses and inflammation regulation. Its diverse functions and involvement in various diseases make Recombinant Human Interleukin-17 A/F Heterodimer a subject of interest in biomedical research and therapeutic development.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System E. coli
Purity 95.0 % by SDS-PAGE
Activity
 The activity as determined by production of IL-6 from mouse 3T3 cells is 3.2ng/ml (3.1x105units/mg).
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 N/A
Structure Heterodimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Lyophilized
Formulation IL-17A/F was lyophilized from a (0.2µm) filtered protein solution containing 0.1% TFA.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MIVKAGITIP RNPGCPNSED KNFPRTVMVN LNIHNRNTNT NPKRSSDYYN RSTSPWNLHR NEDPERYPSV IWEAKCRHLG CINADGNVDY HMNSVPIQQE ILVLRREPPH CPNSFRLEKI LVSVGCTCVT PIVHHVA. MRKIPKVGHT FFQKPESCPP VPGGSMKLDI GIINENQRVS MSRNIESRST SPWNYTVTWD PNRYPSEVVQ AQCRNLGCIN AQGKEDISMN SVPIQQETLV VRRKHQGCSV SFQLEKVLVT VGCTCVTPVI HHVQ.

Storage Instruction

Lyophilized Human IL-17A/F although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Human IL-17A/F should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.

Sample Prep Instruction

It is recommended to reconstitute the lyophilized Interleukin Human IL-17A/F in sterile water at 0.1mg/ml, which can then be further diluted to other aqueous solutions.

References

Not Available
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IL17 A F
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