IL 8 (1-72)

Alternative Names: Neutrophil-activating protein 1, NAP-1, Granulocyte chemotactic protein 1, GCP-1, Monocyte-derived neutrophil chemotactic factor, MDNCF, Monocyte-derived neutrophil-activating peptide, MONAP, Protein 3-10C, T-cell chemotactic factor, IL-8, CXCL8, Emoctakin, K60, NAF, LECT, LUCT, 3-10C, LYNAP, SCYB8, TSG-1, AMCF-I, b-ENAP.

Interleukin-8 (IL-8) is a chemokine that is produced by various cell types, including macrophages, epithelial cells, and endothelial cells. Endothelial cells store IL-8 in Weibel-Palade bodies. Macrophages release chemokines like IL-8 to attract other immune cells to the site of inflammation. IL-8 specifically attracts neutrophils and is therefore referred to as Neutrophil Chemotactic Factor.

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  • Sku: PSB-chm-231-5µg
  • Vendor: ProSpec-Tany
$60.00 USD
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Safety Data Sheet
UniProt Listing
NCBI Link

Product Details

Product Description

Recombinant Human Interleukin-8 (1-72) (CXCL8) is a chemokine protein belonging to the CXC chemokine family. With a molecular weight of approximately 8 kDa, CXCL8 plays a key role in the regulation of immune responses and inflammation. This recombinant protein is commonly used in research studies to investigate the signaling pathways and functions associated with chemokine-mediated immune responses.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System E. coli
Purity 98% by SDS-PAGE
Activity
 Specific Activity of IL8 in chemotaxis of donor PBL neutrophils, threshold concentration corresponding to 10-100 ng/ml corresponding to a Specific Activity of 10,000-100,000IU/mg. Specific Activity of IL8 in chemotaxis of donor PBL neutrophils, threshold concentration corresponding to 10-100 ng/ml corresponding to a Specific Activity of 10,000-100,000IU/mg.
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 N/A
Structure Homodimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Lyophilized
Formulation The IL-8 was lyophilized from a concentrated (1mg/ml) solution in water containing no additives.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

The sequence of the first five N-terminal amino acids was determined and was found to be Ser-Ala-Lys-Glu-Leu.

Storage Instruction

Lyophilized Interleukin-8 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CXCL8 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.

Sample Prep Instruction

It is recommended to reconstitute the lyophilized Interleukin-8 in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

References

Not Available
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IL 8 (1-72)
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