IDI1

Alternative Names: Isopentenyl-diphosphate Delta-isomerase 1, Isopentenyl pyrophosphate isomerase 1, IPP isomerase 1, IPPI1, IDI1, IPP1.

Isopentenyl-diphosphate isomerase 1, part of the IPP isomerase type I family, plays a role in cholesterol biosynthesis as a peroxisomally-localized enzyme catalyzing the conversion of isopentenyl diphosphate (IPP) to dimethylallyl diphosphate (DMAPP). DMAPP is a precursor to farnesyl diphosphate and cholesterol synthesis. Deficiencies in peroxisomal function, as seen in diseases like Zellweger syndrome and neonatal adrenoleukodystrophy, result in decreased activity of IPP isomerase.

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  • Sku: PSB-enz-189-2µg
  • Vendor: ProSpec-Tany
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Product Details

Product Description

Recombinant Human Isopentenyl-Diphosphate Delta Isomerase 1 is a member of the isopentenyl-diphosphate delta isomerase family, responsible for catalyzing the conversion of isopentenyl diphosphate to dimethylallyl diphosphate in the mevalonate pathway. This enzyme plays a key role in the biosynthesis of isoprenoids, essential compounds involved in various cellular processes. With a molecular weight of approximately 20 kDa, Recombinant Human Isopentenyl-Diphosphate Delta Isomerase 1 is a crucial component in the regulation of isoprenoid biosynthesis.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System E. coli
Purity 90% by SDS-PAGE
Activity
 Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 28.6 kDa
Structure Homodimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Frozen
Formulation The IDI1 solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 1mM DTT, 10% glycerol and 0.1M NaCl.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MGSSHHHHHH SSGLVPRGSH MMPEINTNHL DKQQVQLLAE MCILIDENDN KIGAETKKNC HLNENIEKGL LHRAFSVFLF NTENKLLLQQ RSDAKITFPG CFTNTCCSHP LSNPAELEES DALGVRRAAQ RRLKAELGIP LEEVPPEEIN YLTRIHYKAQ SDGIWGEHEI DYILLVRKNV TLNPDPNEIK SYCYVSKEEL KELLKKAASG EIKITPWFKI IAATFLFKWW DNLNHLNQFV DHEKIYRM.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution
​

References

Not Available
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IDI1
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