HMGA2

Alternative Names: Not Available

HMGA2 is a member of the non-histone chromosomal high mobility group (HMG) family. HMG proteins have architectural roles and are essential components of the enhancesome. HMGA2 contains DNA-binding domains and may function as a transcriptional regulator. Deletion, amplification, and rearrangement of the HMGA2 gene have been linked to myxoid liposarcoma, suggesting a role in adipogenesis and mesenchymal differentiation. Studies on mice have shown that knocking out the mouse counterpart of HMGA2 is implicated in diet-induced obesity. HMGA2 is associated with diseases such as diffuse lipomatosis and 12q14 microdeletion syndrome.

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  • Sku: PSB-pro-1469-2µg
  • Vendor: ProSpec-Tany
$60.00 USD
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Safety Data Sheet
UniProt Listing
NCBI Link

Product Details

Product Description

Recombinant Human High Mobility Group AT-Hook 2 (HMGA2) is a protein belonging to the high mobility group (HMG) family. With a molecular weight of approximately 25 kDa, HMGA2 plays a significant role in various cellular processes, including transcriptional regulation and DNA repair. This protein is involved in chromatin remodeling and acts as a transcriptional co-factor, facilitating the binding of transcription factors to DNA. HMGA2 has been extensively studied due to its association with cancer development and progression, making it a potential target for therapeutic interventions.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System E. coli
Purity 80.0% by SDS-PAGE
Activity
 Activity Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 12.8 kDa
Structure Contact for Details
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Frozen
Formulation HMGA2 protein solution (0.25mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.2M NaCl, 50% glycerol, 2mM DTT and 250mM Imidazole.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MSARGEGAGQ PSTSAQGQPA APAPQKRGRG RPRKQQQEPT GEPSPKRPRG RPKGSKNKSP SKAAQKKAEA TGEKRPRGRP RKWPQQVVQK KPAQEETEET SSQESAEEDL EHHHHHH.

Storage Instruction

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution
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References

Not Available
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HMGA2
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