HADH

Alternative Names: EC 1.1.1.35, HAD, HADH1, HHF4, MSCHAD, SCHAD, HCDH, Short-chain 3-hydroxyacyl-CoA dehydrogenase, Medium and short-chain L-3-hydroxyacyl-coenzyme A dehydrogenase, Hydroxyacyl-coenzyme A dehydrogenase, HADH, HADHSC, MGC8392.

HADH, a member of the 3-hydroxyacyl-CoA dehydrogenase enzyme family, plays a crucial role in the beta-oxidation pathway by catalyzing the oxidation of straight-chain 3-hydroxyacyl-CoAs in the mitochondrial matrix. Its enzymatic activity is highest with medium-chain-length fatty acids. Mutations in HADH result in familial hyperinsulinemic hypoglycemia, affecting fatty acid oxidation and energy production.

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  • Sku: PSB-enz-499-5µg
  • Vendor: ProSpec-Tany
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UniProt Listing
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Product Details

Product Description

Recombinant Human Hydroxyacyl-Coenzyme A Dehydrogenase is an enzyme that plays a key role in fatty acid metabolism. Belonging to the dehydrogenase enzyme family, it is responsible for catalyzing the conversion of hydroxyacyl-CoA to 3-ketoacyl-CoA during the beta-oxidation process. With a molecular weight of approximately 40 kDa, this enzyme is crucial for the breakdown of fatty acids for energy production in the body.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System E. coli
Purity 95% by SDS-PAGE
Activity
 Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 N/A
Structure Homodimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Frozen
Formulation The HADH solution contains 20mM Tris-HCl pH-8, 0.1M NaCl and 20% glycerol.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MGSSHHHHHH SSGLVPRGSH MSSSSTASAS AKKIIVKHVT VIGGGLMGAG IAQVAAATGH TVVLVDQTED ILAKSKKGIE ESLRKVAKKK FAENPKAGDE FVEKTLSTIA TSTDAASVVH STDLVVEAIV ENLKVKNELF KRLDKFAAEH TIFASNTSSL QITSIANATT RQDRFAGLHF FNPVPVMKLV EVIKTPMTSQ KTFESLVDFS KALGKHPVSC KDTPGFIVNR LLVPYLMEAI RLYERGDASK EDIDTAMKLG AGYPMGPFEL LDYVGLDTTK FIVDGWHEMD AENPLHQPSP SLNKLVAENK FGKKTGEGFY KYK.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution
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References

Not Available
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HADH
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