GZMB

Alternative Names: Granzyme B, Granzyme-2, GZMB, Fragmentin-2, CTSGL1, Cathepsin G-like 1, CGL1, CGL-1, CSPB, CSP-B, CTLA-1, CTLA1, T-cell serine protease 1-3E, SECT, CCPI, Lymphocyte protease, Human lymphocyte protein, HLP, C11, CTLA1, CTLA-1, Cytotoxic T-lymphocyte proteinase 2.

Granzye-B (GZMB) plays a crucial role in cell-mediated immune responses by promoting target cell lysis. It activates a cascade of caspases, including caspase-3, -7, -9, and -10, which are responsible for executing apoptosis.

  •
  • Sku: PSB-enz-855-5µg
  • Vendor: ProSpec-Tany
$60.00 USD
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Safety Data Sheet
UniProt Listing
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Product Details

Product Description

Recombinant Human Granzyme-B is a serine protease that plays a key role in inducing apoptosis in target cells. Belonging to the granzyme family of proteins, it is primarily expressed by cytotoxic T cells and natural killer cells as part of the immune response against infected or cancerous cells. With a molecular weight of approximately 28 kDa, Recombinant Human Granzyme-B is commonly used in research studies to investigate its role in immune-mediated cell death mechanisms.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System E. coli
Purity 85.0% by SDS-PAGE
Activity
 Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 27.8 kDa
Structure Homodimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Frozen
Formulation GZMB protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH 8.0) and 10% glycerol.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MGSSHHHHHH SSGLVPRGSH MIIGGHEAKP HSRPYMAYLM IWDQKSLKRC GGFLIQDDFV LTAAHCWGSS INVTLGAHNI KEQEPTQQFI PVKRPIPHPA YNPKNFSNDI MLLQLERKAK RTRAVQPLRL PSNKAQVKPG QTCSVAGWGQ TAPLGKHSHT LQEVKMTVQE DRKCESDLRH YYDSTIELCV GDPEIKKTSF KGDSGGPLVC NKVAQGIVSY GRNNGMPPRA CTKVSSFVHW IKKTMKRY.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution
​

References

Not Available
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GZMB
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