GSTM1

Alternative Names: Not Available

Two supergene families encode cytosolic and membrane-bound types of GST. The soluble cytoplasmic mammalian GST consists of 8 classes: alpha, kappa, mu, omega, pi, sigma, theta, and zeta. The mu class of enzymes plays a key role in detoxifying electrophilic compounds by conjugation with glutathione. These enzymes are encoded by genes located in a gene cluster on chromosome 1p13.3 and exhibit high levels of genetic variability. Variations in these genes can impact an individual's susceptibility to carcinogens and toxins, as well as alter the effectiveness and toxicity of certain drugs. Null mutations in the mu class gene have been associated with an increased risk of developing various types of cancers.

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  • Sku: PSB-enz-780-2µg
  • Vendor: ProSpec-Tany
$60.00 USD
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Product Details

Product Description

Recombinant Human Glutathione S-Transferase M1 is a member of the glutathione S-transferase family, which plays a key role in detoxification processes by catalyzing the conjugation of glutathione to a wide range of electrophilic compounds. This protein has a molecular weight of approximately 26 kDa and is commonly used in research and drug development applications due to its ability to bind to and modify a variety of substrates. Its high affinity for glutathione makes it a valuable tool for studying drug metabolism and understanding the mechanisms of drug resistance.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System E. coli
Purity 85.0% by SDS-PAGE
Activity
 Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 23.6 kDa
Structure Homodimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Frozen
Formulation GSTM1 protein solution (0.25mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.4M Urea and 10% glycerol.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MGSSHHHHHH SSGLVPRGSH RSMPMILGYW DIRGLAHAIR LLLEYTDSSY EEKKYTMGDA PDYDRSQWLN EKFKLGLDFP NLPYLIDGAH KITQSNAILC YIARKHNLCG ETEEEKIRVD ILENQTMDNH MQLGMICYNP EFEKLKPKYL EELPEKLKLY SEFLGKRPWF AGNKGLEKIS AYMKSSRFLP RPVFSKMAVW GNK.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution
​

References

Not Available
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GSTM1
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