GRO b

Alternative Names: Macrophage inflammatory protein 2-alpha, MIP2-alpha, MIP2, MIP2A, MIP-2a, chemokine (C-X-C motif) ligand 2, GRO2, Growth-regulated protein beta, Gro-beta, GROb, MGSA beta, SCYB2, MGSA-b, CINC-2a, CXCL2.

CXCL2, also known as MIP2-alpha, is a cytokine in the CXC chemokine family that is 90% similar to CXCL1. It is secreted by monocytes and macrophages to attract white blood cells and stem cells. The gene for CXCL2 is located on human chromosome 4 along with other CXC chemokines. CXCL2 functions by binding to the cell surface receptor CXCR2.

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  • Sku: PSB-chm-309-2µg
  • Vendor: ProSpec-Tany
$60.00 USD
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Safety Data Sheet
UniProt Listing
NCBI Link

Product Details

Product Description

Recombinant Human GRO-beta/MIP-2 (CXCL2) is a chemokine protein belonging to the CXC subfamily. It plays a role in the immune response by attracting and activating neutrophils to sites of inflammation. This protein has a molecular weight of approximately 8.3 kDa. Recombinant Human GRO-beta/MIP-2 (CXCL2) is commonly used in research settings to study the chemotactic properties of neutrophils and their involvement in inflammatory processes.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System E. coli
Purity 98% by SDS-PAGE
Activity
 The Biological activity is calculated by its ability to chemoattract CXCR2 transfected 293 cells using 10-100ng/ml corresponding to a Specific Activity of 10,000-100,000IU/mg. The Biological activity is calculated by its ability to chemoattract CXCR2 transfected 293 cells using 10-100ng/ml corresponding to a Specific Activity of 10,000-100,000IU/mg.
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 N/A
Structure Homodimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Lyophilized
Formulation The protein was lyophilized with no additives.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

The sequence of the first five N-terminal amino acids was determined and was found to be Ala-Pro-Leu-Ala-Thr.

Storage Instruction

Lyophilized CXCL2 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CXCL2 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.

Sample Prep Instruction

It is recommended to reconstitute the lyophilized GRO-beta Human in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

References

Not Available
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GRO b
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