GPX1

Alternative Names: Glutathione peroxidase 1, GPx-1, GSHPx-1, Cellular glutathione peroxidase, GPX1, GPXD, GSHPX1

Glutathione peroxidase 1 (GPX1) is a crucial member of the glutathione peroxidase family, which consists of 8 identified glutathione peroxidases (Gpx1-8) in humans. This enzyme plays a key role in detoxifying hydrogen peroxide and is considered one of the most important antioxidant enzymes in humans. GPX1 is part of the enzymatic antioxidant defense system, protecting DNA, proteins, and lipids from oxidative damage by neutralizing hydrogen and lipid peroxides, which can potentially contribute to the development of prostate cancer. GPX1 is one of the few proteins in higher vertebrates that contains selenocysteine at its active site, coded by the TGA stop codon. Additionally, GPX1 features a polyalanine sequence polymorphism in the N-terminal region, with 3 alleles containing 5, 6, or 7 alanine (ALA) repeats in this sequence. The presence of 5 ALA repeats in the allele has been significantly associated with an increased risk of breast cancer.

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  • Sku: PSB-enz-186-5µg
  • Vendor: ProSpec-Tany
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Safety Data Sheet
UniProt Listing
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Product Details

Product Description

Recombinant Human Glutathione Peroxidase 1 is an enzyme that belongs to the glutathione peroxidase family. It plays a key role in protecting cells from oxidative damage by reducing lipid hydroperoxides and hydrogen peroxide using glutathione as a cofactor. With a molecular weight of approximately 22 kDa, Recombinant Human Glutathione Peroxidase 1 is involved in maintaining cellular redox homeostasis and preventing oxidative stress-related diseases.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System E. coli
Purity 90% by SDS-PAGE
Activity
 Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 24.2 kDa
Structure Homodimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Frozen
Formulation The GPX1 solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 2mM DTT, 30% glycerol and 100mM NaCl.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MGSSHHHHHH SSGLVPRGSH MCAARLAAAA AAAQSVYAFS ARPLAGGEPV SLGSLRGKVL LIENVASLCG TTVRDYTQMN ELQRRLGPRG LVVLGFPCNQ FGHQENAKNE EILNSLKYVR PGGGFEPNFM LFEKCEVNGA GAHPLFAFLR EALPAPSDDA TALMTDPKLI TWSPVCRNDV AWNFEKFLVG PDGVPLRRYS RRFQTIDIEP DIEALLSQGP SCA.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution
​

References

Not Available
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GPX1
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