GPHB5

Alternative Names: Glycoprotein hormone beta-5, GPHB5, GPB5, ZLUT1

Human thyrostimulin belongs to the glycoprotein hormone family and consists of two subunits: the common alpha-subunit and specific beta-subunit. These subunits combine to form a heterodimer, with the alpha-subunit pairing with four distinct beta-subunits to create biologically active hormones: FSH, LH, TSH, and CG. FSH, LH, and TSH play crucial roles in endocrine regulation in the hypothalamus-pituitary axis and activate specific G protein-coupled receptors in the thyroid and gonads. Heterodimeric glycoprotein hormones are found in vertebrates, showing high conservation across species. Thyrostimulin, also known as corticotroph-derived glycoprotein hormone, is a heterodimer of GPHA2 and GPHB5. Recombinant A2/B5 heterodimeric glycoproteins specifically activate human TSH receptors and demonstrate thyroid-stimulating properties. Thyrostimulin acts through a paracrine mechanism with expression in the anterior pituitary, suggesting its involvement in regulating thyroid activity.

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  • Sku: PSB-hor-257-2µg
  • Vendor: ProSpec-Tany
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Safety Data Sheet
UniProt Listing
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Product Details

Product Description

Recombinant Human Thyrostimulin Beta is a protein hormone belonging to the glycoprotein hormone family. It plays a role in regulating thyroid hormone production and secretion. With a molecular weight of approximately 25 kDa, Recombinant Human Thyrostimulin Beta is involved in the activation of the thyroid-stimulating hormone receptor, ultimately influencing thyroid function. This protein is commonly used in research settings to study thyroid-related disorders and hormonal regulation.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System E. coli
Purity 95% by SDS-PAGE
Activity
 Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 N/A
Structure Dimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Lyophilized
Formulation The GPHB5 filtered (0.4µm) and lyophilized from 0.5mg/ml in 0.05M Acetate buffer pH 4.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MRGSHHHHHH GMASASSGNL RTFVGCAVRE FTFLAKKPGC RGLRITTDAC WGRCETWEKP ILEPPYIEAH HRVCTYNETK QVTVKLPNCA PGVDPFYTYP VAIRCDCGAC STATTECETI.

Storage Instruction

Lyophilized Thyrostimulin although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution GPHB5 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.

Sample Prep Instruction

It is recommended to add 0.1M Acetate buffer pH4 to prepare a working stock solution of ~ 0.5 mg/ml and let the lyophilized pellet dissolve completely. For conversion into higher pH value, we recommend intensive dilution by relevant buffer to a concentration of 10μg/ml. In higher concentrations the solubility of this protein is limited. Product is not sterile! Please filter the product by an appropriate sterile filter before using it in the cell culture.

References

Not Available
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GPHB5
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