GNB1

Alternative Names: Guanine Nucleotide Binding Protein (G Protein) Beta Polypeptide 1, GNB1, Transducin Beta Chain 1.

Heterotrimeric G proteins consist of alpha, beta, and gamma subunits that play a crucial role in integrating signals between receptors and effector proteins. The GNB1 gene encodes a beta subunit, which is responsible for regulating alpha subunits and certain signal transduction receptors and effectors. G proteins are involved in multiple transmembrane signaling systems, acting as modulators or transducers. The beta and gamma subunits are essential for GTPase activity, the exchange of GDP for GTP, and the interaction between the G protein and effector proteins.

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  • Sku: PSB-pro-1955-2µg
  • Vendor: ProSpec-Tany
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Title

Product Details

Product Description

Recombinant Human Guanine Nucleotide Binding Protein Beta Polypeptide 1, also known as GNB1, is a protein that belongs to the guanine nucleotide-binding protein (G protein) family. This protein plays a significant role in signal transduction pathways, facilitating the transfer of extracellular signals to intracellular responses. With a molecular weight of approximately 36 kDa, GNB1 acts as a subunit of heterotrimeric G proteins, aiding in the modulation of various cellular processes. Its involvement in multiple signaling cascades highlights its importance in cellular communication and physiological regulation.

Current Lead Time

7-14 Days

Product Specifications

Species
Human
Expression System E. coli
Purity 85.0% by SDS-PAGE
Activity
Activity Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
N/A
Structure Heterotrimer
Endotoxin Concentration
Not Available
Purification Method Not Available
Form
Frozen
Formulation The GNB1 solution (0.25mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.4M UREA and 10% glycerol.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MGSSHHHHHH SSGLVPRGSH MGSMSELDQL RQEAEQLKNQ IRDARKACAD ATLSQITNNI DPVGRIQMRT RRTLRGHLAK IYAMHWGTDS RLLVSASQDG KLIIWDSYTT NKVHAIPLRS SWVMTCAYAP SGNYVACGGL DNICSIYNLK TREGNVRVSR ELAGHTGYLS CCRFLDDNQI VTSSGDTTCA LWDIETGQQT TTFTGHTGDV MSLSLAPDTR LFVSGACDAS AKLWDVREGM CRQTFTGHES DINAICFFPN GNAFATGSDD ATCRLFDLRA DQELMTYSHD NIICGITSVS FSKSGRLLLA GYDDFNCNVW DALKADRAGV LAGHDNRVSC LGVTDDGMAV ATGSWDSFLK IWN.

Storage Instruction

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution

References

Not Available

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GNB1

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