GAMT

Alternative Names: GAMT, Guanidinoacetate N-methyltransferase, PIG2, TP53I2

GAMT is an enzyme that plays a crucial role in the synthesis of creatine by transferring guanidoacetate to creatine using S-adenosylmethionine as a methyl donor. Defects in the GAMT gene result in neurological syndromes and muscle weakness, likely due to creatine deficiency and the buildup of guanidinoacetate in the brain. This enzyme is involved in the generation of creatine from glycine, arginine, and methionine, which are essential protein building blocks. GAMT is important for providing energy for muscle contraction and is also a key player in the functioning of the nervous system. GAMT is primarily active in the liver, pancreas, and kidneys.

  •
  • Sku: PSB-enz-460 -5µg
  • Vendor: ProSpec-Tany
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Product Details

Product Description

Recombinant Human Guanidinoacetate N-Methyltransferase is an enzyme belonging to the methyltransferase family. With a molecular weight of approximately 33 kDa, this enzyme plays a key role in the biosynthesis of creatine by catalyzing the conversion of guanidinoacetate to creatine. Recombinant Human Guanidinoacetate N-Methyltransferase is commonly used in research and biotechnology applications for studying creatine metabolism and related pathways.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System E. coli
Purity 95% by SDS-PAGE
Activity
 Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 N/A
Structure Homodimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Frozen
Formulation The GAMT protein solution contains 20mM Tris-HCl, pH-8, 1mM DTT and 10% Glycerol.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MGSSHHHHHH SSGLVPRGSH MSAPSATPIF APGENCSPAW GAAPAAYDAA DTHLRILGKP VMERWETPYM HALAAAASSK GGRVLEVGFG MAIAASKVQE APIDEHWIIE CNDGVFQRLR DWAPRQTHKV IPLKGLWEDV APTLPDGHFD GILYDTYPLS EETWHTHQFN FIKNHAFRLL KPGGVLTYCN LTSWGELMKS KYSDITIMFE ETQVPALLEA GFRRENIRTE VMALVPPADC RYYAFPQMIT PLVTKG.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution
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References

Not Available
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GAMT
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