GAD1

Alternative Names: Glutamate Decarboxylase 1, GAD1, GAD, GAD-67, GAD67, Glutamate Decarboxylase 1 (Brain, 67kD), Glutamate Decarboxylase 1 (Brain, 67kDa), 67 KDa Glutamic Acid Decarboxylase, 67 KDa Glutamate Decarboxylase, Glutamate Decarboxylase 67 KDa Isoform, EC 4.1.1, EC 4.1.1.15, CPSQ1, SCP.

Glutamate Decarboxylase 1 (GAD1) is an enzyme that converts L-glutamic acid into gamma-aminobutyric acid. GAD1 has been found to play a pathogenic role in type II diabetes and stiff man syndrome. Deficiency in GAD1 can lead to pyridoxine dependency with seizures. Additionally, GAD1 catalyzes the production of GABA.

  •
  • Sku: PSB-enz-789-2µg
  • Vendor: ProSpec-Tany
$60.00 USD
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Safety Data Sheet
UniProt Listing
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Product Details

Product Description

Recombinant Human Glutamate Decarboxylase 1 is an enzyme belonging to the family of glutamate decarboxylases, specifically GAD1. With a molecular weight of approximately 67 kDa, this enzyme plays a key role in the conversion of glutamate to gamma-aminobutyric acid (GABA) in the central nervous system. Recombinant Human Glutamate Decarboxylase 1 is widely used in research and pharmaceutical applications for its ability to modulate GABAergic neurotransmission.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System E. coli
Purity 85.0% by SDS-PAGE
Activity
 Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 27.7 kDa
Structure Dimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Frozen
Formulation The GAD1 solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH8.0), 10% glycerol and 0.4M Urea.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MGSSHHHHHH SSGLVPRGSH MGSMASSTPS SSATSSNAGA DPNTTNLRPT TYDTWCGVAH GCTRKLGLKI CGFLQRTNSL EEKSRLVSAF KERQSSKNLL SCENSDRDAR FRRTETDFSN LFARDLLPAK NGEEQTVQFL LEVVDILLNY VRKTFDRSTK VLDFHHPHQL LEGMEGFNLE LSDHPESLEQ ILVDCRDTLK YGVRTGHPRF FNQLSTGLDI IGLAGEWLTS TANTNMPSDM RECWLLR.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution
​

References

Not Available
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GAD1
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