FUT3

Alternative Names: Blood group Lewis alpha-4-fucosyltransferase, Fucosyltransferase 3, Fucosyltransferase III, FucT-III, FUT3, FT3B, Galactoside 3(4)-L-fucosyltransferase, LE, CD174, Les, Lewis FT.

Fucosyltransferase 3 (FUT3) plays a key role in the expression of several antigens such as Vim-2, Lewis A, Lewis B, sialyl Lewis X, and Lewis X/SSEA-1 by catalyzing specific glycosidic linkages. It is involved in determining blood group Lewis, where individuals who are Lewis-positive (Le+) have an active FUT3 enzyme, while those who are Lewis-negative (Le-) have an inactive enzyme. Additionally, FUT3 also creates 1, 3-L-fucosyl links on the corresponding 1, 4-galactosyl derivative.

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  • Sku: PSB-enz-745-2µg
  • Vendor: ProSpec-Tany
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Product Details

Product Description

Recombinant Human Fucosyltransferase 3 is an enzyme that belongs to the fucosyltransferase family. This enzyme plays a key role in the transfer of fucose residues to glycoproteins and glycolipids. With a molecular weight of approximately 52 kDa, Recombinant Human Fucosyltransferase 3 is involved in various biological processes, including cell adhesion and signaling. Its recombinant form is commonly used in research and biotechnology applications for the modification of glycoproteins.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System E. coli
Purity 80% by SDS-PAGE
Activity
 Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 40.6 kDa
Structure Homodimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Frozen
Formulation The FUT3 solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.4M urea and 10% glycerol.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MGSSHHHHHH SSGLVPRGSH MGSRVSRDDA TGSPRAPSGS SRQDTTPTRP TLLILLWTWP FHIPVALSRC SEMVPGTADC HITADRKVYP QADTVIVHHW DIMSNPKSRL PPSPRPQGQR WIWFNLEPPP NCQHLEALDR YFNLTMSYRS DSDIFTPYGW LEPWSGQPAH PPLNLSAKTE LVAWAVSNWK PDSARVRYYQ SLQAHLKVDV YGRSHKPLPK GTMMETLSRY KFYLAFENSL HPDYITEKLW RNALEAWAVP VVLGPSRSNY ERFLPPDAFI HVDDFQSPKD LARYLQELDK DHARYLSYFR WRETLRPRSF SWALDFCKAC WKLQQESRYQ TVRSIAAWFT.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution
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References

Not Available
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FUT3
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