FNDC5

Alternative Names: Fibronectin Type III Repeat-Containing Protein 2, Fibronectin type III domain-containing protein 5, Fibronectin type III repeat-containing protein, Irisin, FNDC5, FRCP2.

Irisin is a recently discovered hormone that is released by muscles and affects white adipocytes, promoting the browning of white adipose tissue (WAT). This hormone, also known as Fibronectin Type III Domain Containing 5, can lead to weight loss and the activation of brown adipocytes, which can generate heat through uncoupling protein 1 (UCP-1). The mature form of irisin consists of 110 amino acids and has two potential glycosylation sites. While high levels of irisin are found in the heart, its expression is very low, if present at all, in the colon, pancreas, and spleen.

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  • Sku: PSB-pro-1589-2µg
  • Vendor: ProSpec-Tany
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Safety Data Sheet
UniProt Listing
NCBI Link

Product Details

Product Description

Recombinant Human Fibronectin Type III Domain Containing 5 (FNDC5) is a protein that belongs to the fibronectin type III domain-containing protein family. With a molecular weight of approximately 40 kDa, FNDC5 plays a significant role in various physiological processes. It is involved in cell adhesion, tissue development, and regulation of energy metabolism. FNDC5 has garnered attention for its potential role in promoting the browning of white adipose tissue, which could have implications in the treatment of obesity and metabolic disorders. Understanding the functions and mechanisms of FNDC5 holds promise for advancing research in the field of metabolic regulation and therapeutic interventions.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System E. coli
Purity 95% by SDS-PAGE
Activity
 Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 13.8 kDa
Structure Homodimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Lyophilized
Formulation FNDC5 filtered (0.4 µm) and lyophilized from 0.5mg/ml in phosphate buffered saline.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MKHHHHHHASDSPSAPVNVT VRHLKANSAV VSWDVLEDEV VIGFAISQQK KDVRMLRFIQ EVNTTTRSCA LWDLEEDTEY IVHVQAISIQ GQSPASEPVL FKTPREAEKM ASKNKDEVTM KE.

Storage Instruction

Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C. Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C.

Sample Prep Instruction

It is recommended to add deionized water to prepare a working stock solution of approximately 0.5mg/ml and let the lyophilized pellet dissolve completely. FNDC5 is not sterile! Please filter the product by an appropriate sterile filter before using it in the cell culture.

References

Not Available
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FNDC5
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