FKBP5

Alternative Names: FK506-Binding Protein 5, FKBP5, FKBP-5, FKBP-51, FKBP51, FKBP54, 51 KDa FKBP, 51 KDa FK506-Binding Protein, FK506 Binding Protein 5, PPIase FKBP5, PPIASE, Peptidylprolyl Cis-Trans Isomerase, Rotamase, EC 5.2.1.8, T-Cell FK506-Binding Protein, HSP90-Binding Immunophilin, 54 KDa Progesterone Receptor-Associated Immunophilin, Androgen-Regulated Protein 6, FF1 Antigen, AIG6, P54, Ptg-10.

FK506 Binding Protein 5 (FKBP5) is a member of the immunophilin protein family, involved in immunoregulation and key cellular functions. It acts as a cis-trans prolyl isomerase and binds to FK506 and rapamycin. FKBP5 also possesses PPIase and co-chaperone activities. Its role in calcineurin inhibition is assumed, and it interacts with heat-shock protein 90 (HSP90) in unligated steroid receptor complexes. Additionally, FKBP5 functions with mature progesterone receptor complexes alongside 90 kDa heat shock protein and P23 protein.

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  • Sku: PSB-enz-939-2µg
  • Vendor: ProSpec-Tany
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Safety Data Sheet
UniProt Listing
NCBI Link

Product Details

Product Description

Recombinant Human FK506 Binding Protein 5, also known as FKBP5, is a member of the immunophilin protein family. This protein plays a role in the regulation of the immune system and is involved in the binding of the immunosuppressive drug FK506. FKBP5 has a molecular weight of approximately 51 kDa and is commonly used in research studies to investigate its functions and interactions within the immune system.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System E. coli
Purity 90% by SDS-PAGE
Activity
 Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 N/A
Structure Homodimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Lyophilized
Formulation FKBP5 was filtered (0.4µm) and lyophilized in 20mM Tris buffer and 50mM NaCl, pH 7.5.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MKHHHHHHAS MTTDEGAKNN EESPTATVAE QGEDITSKKD RGVLKIVKRV GNGEETPMIG DKVYVHYKGK LSNGKKFDSS HDRNEPFVFS LGKGQVIKAW DIGVATMKKG EICHLLCKPE YAYGSAGSLP KIPSNATLFF EIELLDFKGE DLFEDGGIIR RTKRKGEGYS NPNEGATVEI HLEGRCGGRM FDCRDVAFTV GEGEDHDIPI GIDKALEKMQ REEQCILYLG PRYGFGEAGK PKFGIEPNAE LIYEVTLKSF EKAKESWEMD TKEKLEQAAI VKEKGTVYFK GGKYMQAVIQ YGKIVSWLEM EYGLSEKESK ASESFLLAAF LNLAMCYLKL REYTKAVECC DKALGLDSAN EKGLYRRGEA QLLMNEFESA KGDFEKVLEV NPQNKAARLQ ISMCQKKAKE HNERDRRIYA NMFKKFAEQD AKEEANKAMG KKTSEGVTNE KGTDSQAMEE EKPEGHV.

Storage Instruction

Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C. Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C.

Sample Prep Instruction

It is recommended to add deionized water to prepare a working stock solution of approximately 0.5mg/ml and let the lyophilized pellet dissolve completely. Filter sterilize your culture media/working solutions containing this non-sterile FKBP5 before using in cell culture.

References

Not Available
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FKBP5
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