Filamin

Alternative Names: Not Available

Filamin is a large actin crosslinking protein that helps stabilize the 3D cortical actin network. It consists of an actin binding domain at the N-terminus, followed by a C-terminal rod domain consisting of repeat segments. The rod domain contains approximately 100 residues per repeat and adopts an immunoglobulin-like fold. This type of fold is found in many proteins and is responsible for protein-protein interactions. Mammalian filamin, also known as actin-binding protein (ABP), forms orthogonal actin filament networks in the cortical cytoplasm and anchors membrane proteins to the actin cytoskeleton. It interacts with multiple proteins, including transmembrane receptors, second messenger-associated proteins, protein kinases, phosphatases, and cytoskeletal proteins. These interactions depend on the repeat elements in the rod domain.

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  • Sku: PSB-pro-521-10µg
  • Vendor: ProSpec-Tany
$60.00 USD
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UniProt Listing
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Product Details

Product Description

Filamin is a cytoskeletal protein that belongs to the family of actin-binding proteins. It plays a significant role in organizing the actin cytoskeleton and maintaining cell structure and integrity. Filamin has a molecular weight of approximately 280-300 kDa, making it a substantial protein within the cell. Its intricate interactions with actin filaments enable it to participate in various cellular processes, including cell migration, adhesion, and signaling. Understanding the functional properties and regulatory mechanisms of filamin is crucial for elucidating its role in cellular dynamics and physiological processes.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System Chicken Gizzard
Purity 90% by SDS-PAGE
Activity
 Not Available
Activity Assay
Animal Component Free (ACF) No
Molecular Weight
 N/A
Structure Homodimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Lyophilized
Formulation The protein was lyophilized from a 1mg/ml solution containing 20mM Tris / acetate buffer pH 7.6, 0.1mM EDTA, 2mM DTT, 9M urea and 20mM NaCl.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Storage Instruction

Lyophilized Filamin although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Filamin should be stored at 4°C between 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.

Sample Prep Instruction

It is recommended to reconstitute the lyophilized Filamin protein at a concentration of 0.5mg/ml ;in ;water.

References

Not Available
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Filamin
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