FGF12

Alternative Names: Fibroblast growth factor 12, FGF-12, FGF12, FGF12B, Fibroblast growth factor homologous factor 1, FHF1, FHF-1, Myocyte-activating factor.

FGF12, a member of the Fibroblast Growth Factor (FGF) family, has various biological functions such as mitogenic and cell survival activities. It is known to be crucial in embryonic development, cell growth, tissue repair, and nervous system development. FGF12 lacks the N-terminal signal sequence seen in other FGF family members, but contains basic residue clusters that serve as a nuclear localization signal. When introduced into mammalian cells, FGF12 is localized in the nucleus and is not secreted. FGF12 interacts with IB2 and voltage gated sodium channels, playing a role in intracellular signaling and ion exchange.

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  • Sku: PSB-cyt-1113-2µg
  • Vendor: ProSpec-Tany
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Safety Data Sheet
UniProt Listing
NCBI Link

Product Details

Product Description

Recombinant Human Fibroblast Growth Factor 12 is a protein that belongs to the fibroblast growth factor (FGF) family. It plays a role in cell growth, proliferation, and differentiation. With a molecular weight of approximately 20 kDa, this protein is involved in various cellular processes, including tissue repair and development. Recombinant Human Fibroblast Growth Factor 12 is commonly used in research and therapeutic applications due to its ability to stimulate cell growth and tissue regeneration.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System E. coli
Purity 98.0 % by SDS-PAGE
Activity
 Determined by FGF12 binding ability in a functional ELISA. Immobilized FGFR4/Fc Chimera at 5 µg/mL (100 µL/well) can bind FGF12 with a linear range of 1.6100 ng/mL.
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 20.5 kDa
Structure Dimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Frozen
Formulation Lyophilized from a 0.2μm filtered concentrated solution in PBS, pH7.4 and 1mM DTT.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MESKEPQLKG IVTRLFSQQG YFLQMHPDGT IDGTKDENSD YTLFNLIPVG LRVVAIQGVK ASLYVAMNGE GYLYSSDVFT PECKFKESVF ENYYVIYSST LYRQQESGRA WFLGLNKEGQ IMKGNRVKKT KPSSHFVPKP IEVCMYREQS LHEIGEKQGR SRKSSGTPTM NGGKVVNQDS T.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution
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References

Not Available
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FGF12
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