FETUB

Alternative Names: Fetuin-B, Fetuin-like protein IRL685, FETUB, Gugu, IRL685, 16G2.

Fetuin-B (FETUB) is a protein that belongs to the fetuin family, which is part of the cystatin superfamily proteins. It consists of 2 cystatin domains and is found in the serum. Fetuin-B is expressed in the liver, tongue, and placenta. Its main function is to regulate osteogenesis by inhibiting mineralization. Fetuins, in general, have various roles including involvement in bone formation and breakdown, regulation of hepatocyte growth factor receptors, and response to systemic inflammation. FETUB also plays a role in oocyte maturation by preventing premature hardening of the zona pellucida before fertilization. This is likely achieved by inhibiting the protease activity of ASTL, which is responsible for the cleavage of ZP2 and triggering zona pellucida hardening.

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  • Sku: PSB-pro-1586-2µg
  • Vendor: ProSpec-Tany
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Safety Data Sheet
UniProt Listing
NCBI Link

Product Details

Product Description

Recombinant Human Fetuin-B is a protein that belongs to the fetuin family, which is characterized by its ability to inhibit insulin receptor autophosphorylation. With a molecular weight of approximately 60 kDa, this protein plays a significant role in regulating various physiological processes. Recombinant Human Fetuin-B is widely utilized in scientific research and pharmaceutical applications due to its potential therapeutic implications in conditions such as diabetes and obesity. Its precise mechanism of action and therapeutic benefits make it a valuable tool for investigating insulin signaling pathways and developing novel treatment strategies.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System HEK 293
Purity 90% by SDS-PAGE
Activity
 Not Available
Activity Assay
Animal Component Free (ACF) No
Molecular Weight
 41.8 kDa
Structure Homodimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Lyophilized
Formulation FETUB filtered (0.4µm) and lyophilized from 0.5mg/ml in 0.05M phosphate buffer and 0.075M NaCl, pH 7.4.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

HSHVCGAMSP PQLALNPSAL LSRGCNDSDV LAVAGFALRD INKDRKDGYV LRLNRVNDAQ EYRRGGLGSL FYLTLDVLET DCHVLRKKAW QDCGMRIFFE SVYGQCKAIF YMNNPSRVLY LAAYNCTLRP VSKKKIYMTC PDCPSSIPTD SSNHQVLEAA TESLAKYNNE NTSKQYSLFK VTRASSQWVV GPSYFVEYLI KESPCTKSQA SSCSLQSSDS VPVGLCKGSL TRTHWEKFVS VTCDFFESQA PATGSENSAV NQKPTNLPKV EESQQKNTPP TDSPSKAGPR GSVQYLPDLD DKNSQEKGPQ EAFPVHLDLT TNPQGETLDI SFLFLEPMEE KLVVLPFPKE KARTAECPGP AQNASPLVLP PHHHHHH.

Storage Instruction

Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C. Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C.

Sample Prep Instruction

It is recommended to add deionized water to a working concentration of 0.5mg/ml and let the lyophilized pellet dissolve completely. FETUB is not sterile! Please filter the product by an appropriate sterile filter before using it in the cell culture.

References

Not Available
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FETUB
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