Ferritin

Alternative Names: Not Available

Ferritin is a key protein for storing iron inside cells in both prokaryotes and eukaryotes. It functions by keeping iron soluble and non-toxic and regulates its release. Ferritin is mainly found in the intestinal mucosa, spleen, and liver. It is made up of 24 subunits of heavy and light chains. Different compositions of these subunits can affect iron uptake and release rates in various tissues. Mutations in the gene encoding the light chain of ferritin are associated with several neurodegenerative diseases and hyperferritinemia-cataract syndrome. The genes for the light and heavy chains are located on different chromosomes. The structure of ferritin resembles a hollow sphere, storing iron as Fe(III) in a mineral called ferrihydrite, which is attached to the inner wall of the sphere. To release iron when needed, it must be converted from Fe(III) to Fe(II), and then passes through channels in the spherical structure. Thus, the structure of ferritin is crucial for its ability to store and release iron in a controlled manner. The level of ferritin in the blood directly reflects the amount of iron stored in the body. Ferritin acts as a buffer against iron deficiency by releasing more iron when levels are low. Similarly, it helps store excess iron in cases of iron overload in both the blood and tissues of the body, albeit to a lesser extent.

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  • Sku: PSB-pro-564-200µg
  • Vendor: ProSpec-Tany
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Title

Product Details

Product Description

Human Liver Ferritin is a protein complex that plays a crucial role in iron storage within the liver. Belonging to the ferritin family, it is responsible for maintaining iron homeostasis by sequestering excess iron and releasing it when needed. With a molecular weight of approximately 450 kDa, this protein is composed of 24 subunits that form a hollow sphere capable of accommodating up to 4,500 iron atoms. Its precise regulation and efficient iron storage capacity make Human Liver Ferritin an important component in maintaining iron balance within the body.

Current Lead Time

7-14 Days

Product Specifications

Species
Human
Expression System Human Liver
Purity 96.0% by SDS-PAGE
Activity
Not Available
Activity Assay
Animal Component Free (ACF) No
Molecular Weight
N/A
Structure Homodimer
Endotoxin Concentration
Not Available
Purification Method Not Available
Form
Frozen
Formulation The protein solution is in 0.05M TRIS buffer pH 7.5 containing 1.0M NaCl and 0.09% NaN3.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution

References

Not Available

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Ferritin

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