FCGR3B

Alternative Names: CD16, CD16b, CD16b Antigen, FCG3, FCGR3, FCRIII, FCRIIIb, FCR-10, Fc Fragment Of IgG, Fc Fragment Of IgG, Fc Fragment Of IgG Receptor IIIb, Fc Fragment Of IgG Receptor IIIb, Fc Gamma Receptor IIIb, Fc Gamma Receptor IIIb, Fc-Gamma RIII-Beta, Fc-Gamma RIII, Fc-Gamma RIIIb, Fc-Gamma Receptor IIIb (CD 16), Fc-Gamma Receptor IIIb (CD 16), IGFR3, IgG Fc Receptor III-1, Low Affinity IIIb, Low Affinity IIIb, Low Affinity Immunoglobulin Gamma Fc Region Receptor III-B, Receptor (CD16b), Receptor (CD16), Receptor For (CD16).

FCGR3B, also called CD16b, is an Ig superfamily protein found on the surface of neutrophils. It binds to both complex/aggregated IgG and monomeric IgG. Unlike FCGR3A, FCGR3B does not mediate antibody-dependent cytotoxicity and phagocytosis. Instead, FCGR3B functions to capture immune complexes in the bloodstream without activating neutrophils.

  •
  • Sku: PSB-pro-2486-2µg
  • Vendor: ProSpec-Tany
$60.00 USD
Shipping calculated at checkout.

Contact us directly for international purchases.

Title
Report Product Listing Issue (e.g. Missing Data, or Questions)
Safety Data Sheet
UniProt Listing
NCBI Link

Product Details

Product Description

Recombinant Human CD16b is a glycoprotein that belongs to the immunoglobulin superfamily. It is a cell surface receptor protein primarily expressed on natural killer (NK) cells and neutrophils. With a molecular weight of approximately 50-70 kDa, CD16b plays a significant role in mediating antibody-dependent cell-mediated cytotoxicity (ADCC) and phagocytosis. As an important component of the immune system, understanding the function and characteristics of Recombinant Human CD16b is crucial for studying immune responses and developing therapeutic strategies.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System Sf9 - Baculovirus cells
Purity 90.0 % by SDS-PAGE
Activity
 Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 21.4 kDa
Structure Homodimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Frozen
Formulation FCGR3B protein solution (0.25mg/ml) contains Phosphate Buffered Saline (pH 7.4) and 10% glycerol.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

EDLPKAVVFL EPQWYSVLEK DSVTLKCQGA YSPEDNSTQW FHNENLISSQ ASSYFIDAAT VNDSGEYRCQ TNLSTLSDPV QLEVHIGWLL LQAPRWVFKE EDPIHLRCHS WKNTALHKVT YLQNGKDRKY FHHNSDFHIP KATLKDSGSY FCRGLVGSKN VSSETVNITI TQGLAVSTIS VEHHHHHH.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution
​

References

Not Available
View full details

FCGR3B
SUBHEADING

Recently viewed products