FCGR3A 

Alternative Names: Low affinity immunoglobulin gamma Fc region receptor III-A, CD16a antigen, Fc-gamma RIII-alpha, Fc-gamma RIIIa, Fc-gamma RIII, FcRIII, FcRIIIa, FcR-10, IgG Fc receptor III-2, CD16a, FCGR3A, FCG3, FCGR3, IGFR3, CD16, FCGRIII.

The low affinity immunoglobulin gamma Fc region receptor III-A (FCGR3A) plays a role in removing antigen-antibody complexes from the circulation and carrying out other antibody-dependent immune responses. FCGR3A binds to the gamma subunit of Fc epsilon. The receptor is found on natural killer (NK) cells, where it is anchored to the cell membrane by a transmembrane peptide. FCGR3B, on the other hand, is found on polymorphonuclear neutrophils (PMN) and is anchored by a phosphatidylinositol (PI) linkage. FCGR3A is also found on macrophages, a subset of T-cells, immature thymocytes, and placental trophoblasts. It is involved in mediating antibody-dependent cellular cytotoxicity (ADCC) and phagocytosis. Mutations in the FCGR3A gene are associated with an increased susceptibility to recurrent viral infections, systemic lupus erythematosus, and alloimmune neonatal neutropenia.

  •
  • Sku: PSB-pro-1150-5µg
  • Vendor: ProSpec-Tany
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Safety Data Sheet
UniProt Listing
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Product Details

Product Description

Recombinant Human CD16a, also known as FcγRIIIa, is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. With a molecular weight of approximately 50-70 kDa, CD16a plays a significant role in mediating antibody-dependent cellular cytotoxicity (ADCC) and phagocytosis. As a member of the Fcγ receptor family, CD16a binds to the Fc region of IgG antibodies, facilitating the activation of immune effector cells such as natural killer cells, macrophages, and neutrophils. This interaction triggers a cascade of signaling events, ultimately leading to the elimination of target cells.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System E. coli
Purity 90% by SDS-PAGE
Activity
 Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 N/A
Structure Monomer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Frozen
Formulation FCGR3A protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 1M Urea and 10% glycerol.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSHMRT EDLPKAVVFL EPQWYRVLEK DSVTLKCQGA YSPEDNSTQW FHNESLISSQ ASSYFIDAAT VDDSGEYRCQ TNLSTLSDPV QLEVHIGWLL LQAPRWVFKE EDPIHLRCHS WKNTALHKVT YLQNGKGRKY FHHNSDFYIP KATLKDSGSY FCRGLFGSKN VSSETVNITI TQGLAVSTIS SFFPPGYQ.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution
​

References

Not Available
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FCGR3A 
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