FCAR

Alternative Names: CD89 Antigen, CD89, CTB-61M7.2, FcalphaRI, FCAR Variant 14, Fc Alpha Receptor, Fc Fragment Of IgA, Fc Fragment Of IgA Receptor, IgA Fc Receptor, Immunoglobulin Alpha Fc Receptor, Immunoglobulin alpha Fc receptor

FC Fragment Of IgA Receptor (FCAR) is a key member of the multichain immune recognition receptor family. While it is the most abundant immunoglobulin in mucosal areas, it is the second most common antibody isotype in serum. FCAR plays a role in both pro- and anti-inflammatory responses, depending on the state of bound IgA. Moreover, it serves as a crucial Fc receptor for neutrophil-mediated killing of tumor cells. When FCAR-expressing neutrophils interact with IgA-opsonized tumor cells, they not only exhibit antibody-dependent cell-mediated cytotoxicity but also release the cytokines TNF-α and IL-1β, which promote increased neutrophil migration to the site of action.

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  • Sku: PSB-pro-2471-1µg
  • Vendor: ProSpec-Tany
$60.00 USD
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Safety Data Sheet
UniProt Listing
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Product Details

Product Description

The Recombinant Human Fc Fragment of IgA Receptor is a protein that plays a significant role in immune responses by mediating the binding and internalization of immunoglobulin A (IgA). Belonging to the immunoglobulin superfamily, this receptor is expressed on the surface of various immune cells, including neutrophils, monocytes, and macrophages. With a molecular weight of approximately [insert weight], it acts as a bridge between the IgA antibodies and immune cells, facilitating the clearance of pathogens and immune complex formation. This recombinant protein offers a valuable tool for studying IgA-mediated immune responses and related diseases.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System Sf9 - Baculovirus cells
Purity 85.0 % by SDS-PAGE
Activity
 Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 24.5 kDa
Structure Contact for Details
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Frozen
Formulation FCAR protein solution (0.25mg/ml) contains Phosphate Buffered Saline (pH 7.4) and 10% glycerol.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

ADPQEGDFPM PFISAKSSPV IPLDGSVKIQ CQAIREAYLT QLMIIKNSTY REIGRRLKFW NETDPEFVID HMDANKAGRY QCQYRIGHYR FRYSDTLELV VTGLYGKPFL SADRGLVLMP GENISLTCSS AHIPFDRFSL AKEGELSLPQ HQSGEHPANF SLGPVDLNVS GIYRCYGWYN RSPYLWSFPS NALELVVTDS IHQDYTTQNH HHHHH.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution
​

References

Not Available
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FCAR
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