FBP1

Alternative Names: FBP, FBP1, FBPase 1, Fructose-1,6-bisphosphatase 1, D-fructose-1,6-bisphosphate 1-phosphohydrolase 1

FBP1 is an important protein involved in regulating gluconeogenesis by breaking down fructose 1,6-bisphosphate into fructose 6-phosphate and inorganic phosphate. Deficiency of FBP1 can lead to hypoglycemia and metabolic acidosis. FBP1 plays a role in controlling mouse glucose production and is involved in the metabolism of pancreatic islet cells when working together with phosphofructokinase (PFK).

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  • Sku: PSB-enz-454-5µg
  • Vendor: ProSpec-Tany
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Title

Product Details

Product Description

Recombinant Human Fructose-1,6-Bisphosphatase 1 is an enzyme that plays a key role in gluconeogenesis, the metabolic pathway that generates glucose from non-carbohydrate precursors. Belonging to the fructose-1,6-bisphosphatase family, this enzyme has a molecular weight of approximately 37 kDa. Its catalytic activity involves the hydrolysis of fructose-1,6-bisphosphate into fructose-6-phosphate and inorganic phosphate, contributing to the regulation of blood glucose levels.

Current Lead Time

7-14 Days

Product Specifications

Species
Human
Expression System E. coli
Purity 90% by SDS-PAGE
Activity
Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
39 kDa
Structure Homodimer
Endotoxin Concentration
Not Available
Purification Method Not Available
Form
Frozen
Formulation The FBP1 protein solution is formulated in 20mM Tris-HCl pH-8, 1mM DTT and 10% glycerol.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MGSSHHHHHH SSGLVPRGSH MADQAPFDTD VNTLTRFVME EGRKARGTGE LTQLLNSLCT AVKAISSAVR KAGIAHLYGI AGSTNVTGDQ VKKLDVLSND LVMNMLKSSF ATCVLVSEED KHAIIVEPEK RGKYVVCFDP LDGSSNIDCL VSVGTIFGIY RKKSTDEPSE KDALQPGRNL VAAGYALYGS ATMLVLAMDC GVNCFMLDPA IGEFILVDKD VKIKKKGKIY SLNEGYARDF DPAVTEYIQR KKFPPDNSAP YGARYVGSMV ADVHRTLVYG GIFLYPANKK SPNGKLRLLY ECNPMAYVME KAGGMATTGK EAVLDVIPTD IHQRAPVILG SPDDVLEFLK VYEKHSAQ.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution

References

Not Available

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FBP1

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