FASLG

Alternative Names: Tumor necrosis factor ligand superfamily member 6, Apoptosis antigen ligand, APTL, CD95 ligand, CD95-L, Fas antigen ligand, Fas ligand, FasL, CD178, FASLG, APT1LG1, CD95L, TNFSF6, ALPS1B.

The FASLG protein, belonging to the TNF superfamily, plays a crucial role in immune system regulation and cancer development through its interaction with the Fas receptor. FASLG is expressed on activated T cells as a homotrimer and can induce apoptosis in Fas-expressing cells upon binding. When released from the cell surface, FASLG remains trimeric and retains its ability to bind to Fas, but with reduced apoptosis activation. FASLG also interacts with DcR3, a receptor that lacks signal transduction capabilities. Flawed Fas-mediated apoptosis can lead to oncogenesis and drug resistance. Tumor cells that constitutively express FASLG are able to evade the immune system. Both mouse and human FASLG are effective on respective cells.

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  • Sku: PSB-cyt-031-5µg
  • Vendor: ProSpec-Tany
$60.00 USD
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Safety Data Sheet
UniProt Listing
NCBI Link

Product Details

Product Description

Recombinant Human FAS Ligand is a protein belonging to the tumor necrosis factor (TNF) family. It plays a critical role in the regulation of apoptosis, or programmed cell death, by binding to its receptor FAS. This protein has a molecular weight of approximately 18-24 kDa. Recombinant Human FAS Ligand is commonly used in research and therapeutic applications due to its ability to induce apoptosis in target cells through the FAS-FASL signaling pathway.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System E. coli
Purity 90% by SDS-PAGE
Activity
 Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 19.6 kDa
Structure Homotrimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Frozen
Formulation FASLG protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.4M urea and 10% glycerol.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MGSSHHHHHH SSGLVPRGSH MQIGHPSPPP EKKELRKVAH LTGKSNSRSM PLEWEDTYGI VLLSGVKYKK GGLVINETGL YFVYSKVYFR GQSCNNLPLS HKVYMRNSKY PQDLVMMEGK MMSYCTTGQM WARSSYLGAV FNLTSADHLY VNVSELSLVN FEESQTFFGL YKL.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution
​

References

Not Available
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FASLG
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