FABP4 - Human

Alternative Names: Fatty acid-binding protein adipocyte, Fatty acid-binding protein 4, Adipocyte lipid-binding protein, AFABP, ALBP, A-FABP, FABP4.

Adipocyte FABP4 is a small protein that belongs to the FABP family. It has the ability to bind fatty acids and similar compounds within its internal cavity. FABP4 is only expressed in mature adipocytes and plays an important role in regulating the function of these cells. In mice, mutations in FABP4 have been shown to protect against insulin resistance in the presence of both dietary and genetic obesity. FABP4-deficient mice also have decreased lipid breakdown and improved dyslipidemia. Recent studies have found that FABP4 is also expressed in macrophages and is involved in regulating inflammatory responses and cholesterol accumulation. When FABP4 is absent in these cells, it provides significant protection against atherosclerosis. These findings suggest that FABP4 plays a central role in the development of metabolic syndrome by acting in both adipocytes and macrophages.

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  • Sku: PSB-pro-1568-2µg
  • Vendor: ProSpec-Tany
$60.00 USD
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Safety Data Sheet
UniProt Listing
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Product Details

Product Description

Human Fatty Acid Binding Protein-4 (FABP4), also known as adipocyte protein 2 (aP2), is a member of the fatty acid binding protein (FABP) family. FABP4 is a small cytoplasmic protein that plays a role in the transport and metabolism of fatty acids within adipocytes and macrophages. It has a molecular weight of approximately 15 kDa. FABP4 is involved in various physiological processes, including lipid homeostasis, insulin sensitivity, and inflammation, making it a subject of interest in the study of metabolic disorders such as obesity and diabetes.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System Human Adipose Tissue
Purity 85.0% by SDS-PAGE
Activity
 Not Available
Activity Assay
Animal Component Free (ACF) No
Molecular Weight
 14.587 kDa
Structure Homodimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Lyophilized
Formulation FABP4 protein filtered (0.4µm) and lyophilized in 0.5mg/ml in 0.05M phosphate buffer and 0.075M NaCl, pH 6.5.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

CDAFVGTWKL VSSENFDDYM KEVGVGFATR KVAGMAKPNM IISVNGDVIT IKSESTFKNT EISFILGQEF DEVTADDRKV KSTITLDGGV LVHVQKWDGK STTIKRKRED DKLVVECVMK GVTSTRVYER A.

Storage Instruction

Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C. Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C.

Sample Prep Instruction

It is recommended to add deionized water to prepare a working stock solution of approximately 0.5 mg/ml and let the lyophilized pellet dissolve completely. Product is not sterile! Please filter the product by an appropriate sterile filter before using it in the cell culture.

References

Not Available
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FABP4 - Human
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