F9

Alternative Names: Factor IX, Coagulation factor IX, EC 3.4.21.22, Christmas factor, Plasma thromboplastin component, PTC, F9, FIX, HEMB, MGC129641, MGC129642, GLA domain.

Human Factor IX, also known as Christmas-Factor, is a glycoprotein synthesized in the liver. It belongs to the serine proteases system and is part of the S1 peptidase family. Lack of Factor-IX leads to Hemophilia-B or Christmas Disease. The N-terminus region of Factor-IX contains 12xGla residues that assist in the calcium-dependent binding of Factor-IX to the phospholipid surface. It can be activated by either factor XIa or the factor VIIa/tissue factor/phospholipid complex. This activation results in the formation of intermediate IXa, which is then converted to the fully active form IXab. Coagulation factor IX binds initially to exosites on the factor XIa heavy chain and then interacts at the active site, leading to bond cleavage. Interacting with the erythrocyte membrane, Factor-IX activation triggers intrinsic coagulation. Chaperones and lectins work together to ensure proper folding of Factor-IX and retention of mutant molecules. Human Factor IX, activated through either the Contact or Tissue Factor Pathway, activates Factor X to Xa.

  •
  • Sku: PSB-pro-353-50µg
  • Vendor: ProSpec-Tany
$660.00 USD
Shipping calculated at checkout.

Contact us directly for international purchases.

Title
Report Product Listing Issue (e.g. Missing Data, or Questions)
Safety Data Sheet
UniProt Listing
NCBI Link

Product Details

Product Description

Human Coagulation Factor IX, also known as FIX, is a glycoprotein that plays a crucial role in the blood coagulation cascade. It belongs to the serine protease family and is synthesized in the liver as a single-chain precursor protein. FIX has a molecular weight of approximately 55 kilodaltons and circulates in the blood plasma in an inactive form. Upon activation, it forms a complex with other coagulation factors, leading to the formation of a fibrin clot, which is essential for hemostasis. Understanding the structure and function of Human Coagulation Factor IX is of utmost significance in the management and treatment of bleeding disorders.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System Human Plasma
Purity 95% by SDS-PAGE
Activity
 The activity per mg was tested and found to be 306.5 PEU/mg. The activity per mg was tested and found to be 306.5 PEU/mg.
Activity Assay
Animal Component Free (ACF) No
Molecular Weight
 N/A
Structure Dimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Lyophilized
Formulation The Factor-IX was lyophilized from a sterile solution containing 20mM Tris-HCl pH-7.4, 0.1M NaCl and 1mM Benzamidine.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Storage Instruction

Lyophilized Factor-IX although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Factor-IX should be stored at 4°C between 2-7 days and for future use below -18°C.Please prevent freeze-thaw cycles.

Sample Prep Instruction

It is recommended to reconstitute the lyophilized 100U Factor-IX in sterile 100µl of 18MΩ-cm H2O, which can then be further diluted to other aqueous solutions.

References

Not Available
View full details

F9
SUBHEADING

Recently viewed products