F8

Alternative Names: Coagulation factor VIII, Antihemophilic factor, Procoagulant component, AHF, F8, F8C, F8B, FVIII, HEMA, DXS1253E, F8 protein.

Coagulation factor VIII is an important part of the blood coagulation process. It acts as a cofactor for factor IXa, which helps convert factor X to its activated form Xa. This gene produces two different types of transcripts. The first type, transcript variant 1, produces a large glycoprotein called isoform a. This glycoprotein circulates in the plasma and forms a noncovalent complex with von Willebrand factor. It undergoes multiple cleavage events. The second type, transcript variant 2, produces a smaller protein called isoform b. This protein consists mainly of the phospholipid binding domain of factor VIIIc, which is essential for coagulation activity. Mutations in this gene lead to hemophilia A, a common X-linked recessive coagulation disorder.

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  • Sku: PSB-pro-317-200IU
  • Vendor: ProSpec-Tany
$540.00 USD
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Title
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Safety Data Sheet
UniProt Listing
NCBI Link

Product Details

Product Description

Human Coagulation Factor VIII is a glycoprotein that plays a vital role in the blood clotting process. Belonging to the family of coagulation factors, it is a key component of the intrinsic pathway. With a molecular weight of approximately 330 kDa, Factor VIII is synthesized in the liver and endothelial cells, and circulates in the blood plasma as an inactive procofactor. Upon activation, it interacts with other coagulation factors to form a complex cascade, ultimately leading to the formation of a stable blood clot. Understanding the characteristics and function of Human Coagulation Factor VIII is crucial for managing bleeding disorders and developing effective therapeutic interventions.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System Human Plasma
Purity
Activity
 The potency was found to be 10 Units/mg.
Activity Assay
Animal Component Free (ACF) No
Molecular Weight
 N/A
Structure Homodimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Lyophilized
Formulation The lyophilized protein 200IU/ml was lyophilized from a sterile solution containing 1.5% Glycine, 160mM Calcium chloride and 25mM NaCitrate and 25mM NaCl.

*For Research Use Only

Notes

Human Virus Test: The plasma is collected from donors with Hepatitis B vaccinated.  Each unit of plasma has been tested for HBsAg, Anti-HIV-1/2 plus O and Anti-HCV by using the imported kits which are approved by Federal Drug Administration (FDA).

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

Check Uniprot Link

Storage Instruction

Lyophilized Factor-VIII although stable at room temperature for 1 week, should be stored desiccated between 2-8° C. Upon reconstitution Factor-VIII should be stored at 4° C.

Sample Prep Instruction

When using the protein as an attachment factor, wash the urea off after attaching the fibronectin to the growth surface (plate or dish).

References

Not Available
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F8
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