EYA2

Alternative Names: EAB1, Eyes absent homolog 2 (Drosophila), EC 3.1.3.48.

EYA2, a member of the tyrosine phosphatase family, dephosphorylates the 'Tyr-142' residue of histone H2AX (H2AXY142ph). By doing so, EYA2 facilitates efficient DNA repair by promoting the recruitment of DNA repair complexes involving MDC1. The role of EYA2 as a histone phosphatase may elucidate its involvement in transcriptional regulation during organ development.

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  • Sku: PSB-pro-1071-2µg
  • Vendor: ProSpec-Tany
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Title

Product Details

Product Description

Recombinant Human Eyes Absent Homolog 2 (EYA2) is a protein that plays a significant role in various biological processes. Belonging to the EYA family, it is involved in the regulation of gene expression, cell proliferation, and differentiation. With a weight of approximately X kDa, EYA2 acts as a transcriptional coactivator and possesses protein phosphatase activity. Its intricate involvement in developmental processes and cellular signaling pathways makes it a subject of extensive scientific research.

Current Lead Time

7-14 Days

Product Specifications

Species
Human
Expression System E. coli
Purity 90% by SDS-PAGE
Activity
Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
33.2 kDa
Structure Homodimer
Endotoxin Concentration
Not Available
Purification Method Not Available
Form
Frozen
Formulation The EYA2 solution (0.5mg/1ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 1mM DTT and 40% glycerol.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MGSSHHHHHH SSGLVPRGSH MGSMERVFVW DLDETIIIFH SLLTGTFASR YGKDTTTSVR IGLMMEEMIF NLADTHLFFN DLEDCDQIHV DDVSSDDNGQ DLSTYNFSAD GFHSSAPAAN LCLGSGVHGG VDWMRKLAFR YRRVKEMYNT YKNNVGGLIG TPKRETWLQL RAELEALTDL WLTHSLKALN LINSRPNCVN VLVTTTQLIP ALAKVLLYGL GSVFPIENIY SATKTGKESC FERIMQRFGR KAVYVVIGDG VEEEQGAKKH NMPFWRISCH ADLEALRHAL ELEYL.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution

References

Not Available

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EYA2

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