EXOSC5

Alternative Names: Chronic myelogenous leukemia tumor antigen 28, exosome complex exonuclease RRP46, Ribosomal RNA-processing protein 46, Exosome component 5, RRP41B, hRrp46p, p12B, CML28.

EXOSC5, a member of the RNase PH family, collaborates with Exosome component 8 and Exosome component 1. It acts as a non-catalytic component of the RNA exosome complex, displaying 3'->5' exoribonuclease activity. EXOSC5 plays a significant role in various cellular RNA processing and degradation processes. Furthermore, it is expressed in a wide range of hematopoietic and epithelial tumor cell lines, apart from testis, while being absent in standard hematopoietic tissues and other regular tissues.

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  • Sku: PSB-pro-1059-5µg
  • Vendor: ProSpec-Tany
$60.00 USD
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Title

Product Details

Product Description

Recombinant Human Exosome Component 5, also known as REXO5, is a protein that belongs to the exosome complex family. With a molecular weight of approximately 35 kilodaltons, REXO5 plays a significant role in the biogenesis and function of exosomes, which are extracellular vesicles involved in intercellular communication and the transport of various biomolecules. This recombinant protein is produced through genetic engineering techniques, allowing for its controlled and efficient production for research purposes. Understanding the functions and mechanisms of REXO5 can provide valuable insights into the intricate processes of exosome-mediated communication in diverse biological contexts.

Current Lead Time

7-14 Days

Product Specifications

Species
Human
Expression System E. coli
Purity 90% by SDS-PAGE
Activity
Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
27.5 kDa
Structure Homodimer
Endotoxin Concentration
Not Available
Purification Method Not Available
Form
Frozen
Formulation The EXOSC5 solution (0.5mg/1ml) contains PBS buffer (pH 7.4), 200mM Nacl, 2mM DTT and 30% glycerol.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MGSSHHHHHH SSGLVPRGSH MMEEETHTDA KIRAENGTGS SPRGPGCSLR HFACEQNLLS RPDGSASFLQ GDTSVLAGVY GPAEVKVSKE IFNKATLEVI LRPKIGLPGV AEKSRERLIR NTCEAVVLGT LHPRTSITVV LQVVSDAGSL LACCLNAACM ALVDAGVPMR ALFCGVACAL DSDGTLVLDP TSKQEKEARA VLTFALDSVE RKLLMSSTKG LYSDTELQQC LAAAQAASQH VFRFYRESLQ RRYSKS

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution

References

Not Available

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EXOSC5

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