EXOSC4

Alternative Names: Exosome Complex Component RRP41, Exosome Complex Exonuclease RRP41, Ribosomal RNA-Processing Protein 41, Exosome Component 4, SKI6, Ski6p, RRP41A, p12A.

EXOSC4 is a non-catalytic component of the RNA exosome complex, which plays a role in various cellular RNA processing and degradation processes. Specifically, in the nucleus, the RNA exosome complex helps with the proper maturation of stable RNA species (such as rRNA, snRNA, and snoRNA), eliminates unwanted RNA processing by-products and non-coding transcripts (like antisense RNA species and PROMPTs), and removes mRNAs with processing defects. In doing so, it regulates the export of these RNA molecules to the cytoplasm.

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  • Sku: PSB-pro-1792-5µg
  • Vendor: ProSpec-Tany
$60.00 USD
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Safety Data Sheet
UniProt Listing
NCBI Link

Product Details

Product Description

Recombinant Human Exosome Component 4, also known as REXO4, is a vital protein involved in the formation and function of exosomes. Exosomes are small extracellular vesicles that play a crucial role in intercellular communication and the transportation of various molecules, including proteins, RNA, and lipids. REXO4 belongs to the exosome complex component family and has a molecular weight of approximately X kDa. This protein's significance lies in its contribution to the biogenesis and cargo sorting of exosomes, making it an important target for further research in understanding cellular communication and potential therapeutic applications.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System E. coli
Purity 85.0% by SDS-PAGE
Activity
 Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 28.8 kDa
Structure Monomer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Frozen
Formulation EXOSC4 protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.4M Urea and 10% glycerol.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MGSSHHHHHH SSGLVPRGSH MGSMAGLELL SDQGYRVDGR RAGELRKIQA RMGVFAQADG SAYIEQGNTK ALAVVYGPHE IRGSRARALP DRALVNCQYS SATFSTGERK RRPHGDRKSC EMGLQLRQTF EAAILTQLHP RSQIDIYVQV LQADGGTYAA CVNAATLAVL DAGIPMRDFV CACSAGFVDG TALADLSHVE EAAGGPQLAL ALLPASGQIA LLEMDARLHE DHLERVLEAA AQAARDVHTL LDRVVRQHVR EASILLGD

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution
​

References

Not Available
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EXOSC4
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