EXOSC10

Alternative Names: Exosome component 10, EXOSC10, Polymyositis/scleroderma autoantigen 2, PMSCL2, Autoantigen PM/Scl 2, PM/Scl-100, Polymyositis/scleroderma autoantigen 100 kDa, P100 polymyositis-scleroderma overlap syndrome-associated autoantigen, PM-Scl, p2, p3, p4, RRP6, Rrp6p.

EXOSC10 is a nucleolar protein and part of the "PM/Scl complex" or "nuclear exosome," which is an RNA-processing complex composed of exoribonucleases. Autoantibodies against EXOSC10 are found in patients with polymyositis, scleroderma, or polymyositis/scleroderma overlap syndromes. While some sera contain antibodies to other components of the exosome complex, almost all patients with autoantibodies against the PM/Scl complex also have EXOSC10 antibodies. This specificity serves as an important marker. The presence of EXOSC10 autoantibodies is a comparatively positive prognostic sign in polymyositis/scleroderma overlap syndrome, contrasting with the poor prognosis associated with other myositis and systemic sclerosis specific autoantibodies.

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  • Sku: PSB-pro-444-5µg
  • Vendor: ProSpec-Tany
$60.00 USD
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Title

Product Details

Product Description

Recombinant Human Exosome Component 10 (EXOSC10) is a protein that plays a crucial role in the degradation and processing of various RNA molecules within the cell. Belonging to the exosome complex, it is an essential component involved in RNA surveillance and turnover. With a molecular weight of approximately X kDa, EXOSC10 is an integral member of the exosome family, which is responsible for maintaining cellular homeostasis by regulating RNA stability and quality control mechanisms. Its precise functions and interactions within the exosome complex make it a subject of interest in various research fields, including RNA biology and disease mechanisms.

Current Lead Time

7-14 Days

Product Specifications

Species
Human
Expression System Sf9 - Insect cells
Purity 95 % by SDS-PAGE
Activity
Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
N/A
Structure Homodimer
Endotoxin Concentration
Not Available
Purification Method Not Available
Form
Frozen
Formulation EXOSC10 is supplied in 20mM HEPES, pH-7.5, 100mM NaCl, 0.01mM EDTA, 0.02% SDS.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

Check Uniprot Link

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution

References

Not Available

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EXOSC10

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