Exendin 4

Alternative Names: Not Available

Exedin-4 Recombinant is a peptide-1 receptor agonist derived from the hormone produced in the gut of the Gila monster. This hormone helps stimulate insulin production without causing dangerously low blood sugar levels, unlike some other anti-diabetes medications. Researchers have found that Exedin-4 can lead to weight loss in patients with Type 2 diabetes, unlike other treatments that may cause weight gain. In addition, Exedin-4 has shown to enhance glucose-dependent secretion, suppress high secretion levels, slow gastric emptying, promote B-cell proliferation and neogenesis, and increase acinar cAMP levels without stimulating amylase release.

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  • Sku: PSB-hor-269-20µg
  • Vendor: ProSpec-Tany
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Title

Product Details

Product Description

Recombinant Exendin-4 is a synthetic version of the peptide hormone Exendin-4, which is found in the saliva of the Gila monster lizard. Belonging to the glucagon-like peptide-1 (GLP-1) family, Recombinant Exendin-4 is commonly used in the treatment of type 2 diabetes due to its ability to regulate blood sugar levels. With a molecular weight of approximately 4186.6 g/mol, this medication works by stimulating insulin release and inhibiting glucagon secretion, ultimately helping to improve glycemic control in patients with diabetes.

Current Lead Time

7-14 Days

Product Specifications

Species
Reptile
Expression System E. coli
Purity 96.0 % by SDS-PAGE
Activity
Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
N/A
Structure Dimer
Endotoxin Concentration
Not Available
Purification Method Not Available
Form
Lyophilized
Formulation Lyophilized from a 0.2μm filtered concentrated solution in PBS, pH 7.4.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

HGEGTFTSDL SKQMEEEAVR LFIEWLKNGG PSSGAPPPS.

Storage Instruction

Lyophilized Exendin Recombinant although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Exendin-4 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.

Sample Prep Instruction

It is recommended to reconstitute the lyophilized Exendin Recombinant in sterile 18MΩ-cm H2O not less than 100 µg/ml, which can then be further diluted to other aqueous solutions.

References

Not Available

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Exendin 4

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