ESM1, HEK

Alternative Names: Endothelial cell-specific molecule 1, ESM-1, ESM1, endocan

Endothelial cell-specific molecule 1 (ESM1) is a proteoglycan secreted by endothelial cells, primarily in the human lung and kidney tissues. Its mRNA expression is influenced by inflammatory cytokines. ESM1 plays a significant role in the interactions between lung endothelial cells and leukocytes. It is also found in various epithelial tissues and adipocytes. ESM1 is involved in angiogenesis and promotes the growth of new blood vessels. Its expression is increased by TNF alpha, IL1 beta, or lipopolysaccharide, but decreased by IFN gamma. Studies have shown that genetically modified cells with high levels of ESM1 can lead to tumor formation, suggesting a potential involvement of ESM1 in the development of tumors in living organisms.

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  • Sku: PSB-pro-2476-2µg
  • Vendor: ProSpec-Tany
$60.00 USD
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Title

Product Details

Product Description

Recombinant Human Endothelial Cell-Specific Molecule 1 (HEK) is a protein that belongs to the immunoglobulin superfamily. With a molecular weight of approximately X kDa, HEK plays a significant role in endothelial cell adhesion and migration. This protein is involved in various physiological processes, including angiogenesis and inflammation. Understanding the function and regulation of HEK is crucial for elucidating its implications in vascular biology and related diseases.

Current Lead Time

7-14 Days

Product Specifications

Species
Human
Expression System HEK 293
Purity 95.0 % by SDS-PAGE
Activity
Not Available
Activity Assay
Animal Component Free (ACF) No
Molecular Weight
19.5 kDa
Structure Homodimer
Endotoxin Concentration
Not Available
Purification Method Not Available
Form
Lyophilized
Formulation ESM1 filtered (0.4 µm) and lyophilized from 0.5mg/ml in phosphate buffered saline.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

WSNNYAVDCP QHCDSSECKS SPRCKRTVLD DCGCCRVCAA GRGETCYRTV SGMDGMKCGP GLRCQPSNGE DPFGEEFGIC KDCPYGTFGM DCRETCNCQS GICDRGTGKC LKFPFFQYSV TKSSNRFVSL TEHDMASGDG NIVREEVVKE NAAGSPVMRK WLNPR HHHHH HHHHH.

Storage Instruction

Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C. Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C.

Sample Prep Instruction

It is recommended to add deionized water to prepare a working stock solution of approximately 0.5mg/ml and let the lyophilized pellet dissolve completely. ESM1 is not sterile! Please filter the product by an appropriate sterile filter before using it in the cell culture.

References

Not Available

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ESM1, HEK

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