ESM1

Alternative Names: Endocan, ESM1, ESM-1, Endothelial cell-specific molecule 1.

Endothelial cell-specific molecule 1 (ESM1) is a proteoglycan secreted by endothelial cells in the human lung and kidney tissues. Its mRNA expression is controlled by inflammatory cytokines. ESM1 plays a significant role in lung endothelial cell-leukocyte interactions, as well as in various epithelia and adipocytes. It is involved in angiogenesis and promotes angiogenic sprouting. ESM1 expression is increased by TNF alpha, IL1 beta, or lipopolysaccharide, while it is decreased by IFN gamma. Studies suggest that ESM1 may contribute to the development of tumors in vivo, as genetically modified cells with overexpressed ESM1 can lead to tumor formation.

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  • Sku: PSB-pro-1328-5µg
  • Vendor: ProSpec-Tany
$60.00 USD
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Title

Product Details

Product Description

Recombinant Human Endothelial Cell-Specific Molecule 1 (ESM-1) is a protein belonging to the family of adhesion molecules. With a molecular weight of approximately X kDa, ESM-1 plays a significant role in mediating cell-cell interactions and regulating endothelial cell functions. This protein is involved in various physiological processes, including angiogenesis, inflammation, and vascular permeability. By promoting adhesion and migration of endothelial cells, ESM-1 contributes to the maintenance of vascular homeostasis. Understanding the functions and mechanisms of ESM-1 can provide valuable insights into the pathogenesis of several vascular disorders.

Current Lead Time

7-14 Days

Product Specifications

Species
Human
Expression System E. coli
Purity 90% by SDS-PAGE
Activity
Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
20.5 kDa
Structure Homodimer
Endotoxin Concentration
Not Available
Purification Method Not Available
Form
Frozen
Formulation ESM1 protein solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 2M Urea and 10% glycerol.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MGSSHHHHHH SSGLVPRGSH MGSWSNNYAV DCPQHCDSSE CKSSPRCKRT VLDDCGCCRV CAAGRGETCY RTVSGMDGMK CGPGLRCQPS NGEDPFGEEF GICKDCPYGT FGMDCRETCN CQSGICDRGT GKCLKFPFFQ YSVTKSSNRF VSLTEHDMAS GDGNIVREEV VKENAAGSPV MRKWLNPR.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution

References

Not Available

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ESM1

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