EREG, HEK

Alternative Names: Ep, EPR, Epiregulin, ER, Proepiregulin, EREG.

Epiregulin is a member of the EGF family and acts as a ligand for EGFR and other members of the ERBB family of tyrosine-kinase receptors. It is mainly found in the placenta, peripheral blood leukocytes, and specific types of carcinomas. Epiregulin promotes the growth of certain cells like keratinocytes and hepatocytes, but also inhibits the growth of some tumor-derived epithelial cell lines. In humans, Epiregulin is produced as a 19.0 kDa transmembrane precursor protein that undergoes proteolytic cleavage to form a 6.0 kDa mature secreted sequence.

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  • Sku: PSB-cyt-1206-2µg
  • Vendor: ProSpec-Tany
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UniProt Listing
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Product Details

Product Description

Recombinant Human Epiregulin, HEK is a member of the epidermal growth factor (EGF) family, a group of proteins that play a key role in cell growth and proliferation. This protein is produced in human embryonic kidney (HEK) cells using recombinant DNA technology. With a molecular weight of approximately 6.2 kDa, Recombinant Human Epiregulin, HEK is commonly used in research and biotechnological applications for its ability to stimulate cell signaling pathways involved in tissue development and repair.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System HEK 293
Purity 90.0% by SDS-PAGE
Activity
 Measured in a cell proliferation assay using Balb/3T3 mouse embryonic fibroblast cells. The ED50 range ≤ 1ug/ml.
Activity Assay
Animal Component Free (ACF) No
Molecular Weight
 N/A
Structure Dimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Frozen
Formulation EREG protein (0.25mg/ml) contains 10% glycerol and Phosphate-Buffered Saline (pH 7.4).

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

DGSMVSITKC SSDMNGYCLH GQCIYLVDMS QNYCRCEVGY TGVRCEHFFL LEPKSCDKTH TCPPCPAPEL LGGPSVFLFP PKPKDTLMIS RTPEVTCVVV DVSHEDPEVK FNWYVDGVEV HNAKTKPREE QYNSTYRVVS VLTVLHQDWL NGKEYKCKVS NKALPAPIEK TISKAKGQPR EPQVYTLPPS RDELTKNQVS LTCLVKGFYP SDIAVEWESN GQPENNYKTT PPVLDSDGSF FLYSKLTVDK SRWQQGNVFS CSVMHEALHN HYTQKSLSLS PGKHHHHHH

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution
​

References

Not Available
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EREG, HEK
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