EREG

Alternative Names: Epiregulin, EREG, ER.

Epiregulin, a member of the EGF family, acts as a ligand for the EGFR and most members of the ERBB family of tyrosine-kinase receptors. It is primarily expressed in the placenta, peripheral blood leukocytes, and specific carcinomas of the bladder, lung, kidney, and colon. Epiregulin stimulates the proliferation of various cell types, including keratinocytes, hepatocytes, fibroblasts, and vascular smooth muscle cells, while also inhibiting the growth of certain tumor-derived epithelial cell lines. The human Epiregulin is initially produced as a glycosylated 19.0 kDa transmembrane precursor protein, which undergoes proteolytic cleavage to produce a 6.0 kDa mature secreted sequence.

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  • Sku: PSB-cyt-609-5µg
  • Vendor: ProSpec-Tany
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Safety Data Sheet
UniProt Listing
NCBI Link

Product Details

Product Description

Recombinant Human Epiregulin is a protein belonging to the epidermal growth factor (EGF) family, known for its role in cell proliferation and differentiation. With a molecular weight of approximately 6.2 kDa, this protein plays a crucial role in various cellular processes, including wound healing and tissue regeneration. Recombinant Human Epiregulin is commonly used in research and therapeutic applications due to its potent mitogenic and cell survival properties.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System E. coli
Purity 97.0% by SDS-PAGE
Activity
 The ED50 was determined by the dose-dependent stimulation of the proliferation of murine Balb/3T3 cells is 2.0 ng/ml, corresponding to a specific activity of 500,000 units/mg.
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 N/A
Structure Dimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Lyophilized
Formulation Epiregulin was lyophilized from 0.5mg/ml solution ciontaing 20mM PBS buffer pH-7.4 containing 20mM sodium chloride.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

VAQVSITKC SSDMNGYCLH GQCIYLVDMS QNYCRCEVGY TGVRCEHFFL.

Storage Instruction

Lyophilized Epiregulin although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Epiregulin should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.

Sample Prep Instruction

It is recommended to reconstitute the lyophilized Epiregulin in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

References

Not Available
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EREG
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