ErbB3

Alternative Names: Receptor tyrosine-protein kinase erbB-3, c-erbB3, Tyrosine kinase-type cell surface receptor HER3, ErbB3, HER3, EC 2.7.10.1.

ErbB3, also known as Her3, is a type I membrane glycoprotein within the ErbB family of tyrosine kinase receptors. Unlike other family members, ErbB3 has a defective kinase domain. ErbB3 is found in various cell types including keratinocytes, melanocytes, skeletal muscle cells, embryonic myoblasts, and Schwann cells. It acts as a low affinity receptor for the heregulins (HRG) and can stimulate specific antibody production to inhibit tumor cell growth. ErbB3 is used as a therapeutic for breast cancer, particularly in cases with high levels of ErbB2 expression. Its effectiveness against cancer classifies it as a therapeutic agent.

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  • Sku: PSB-pka-342-5µg
  • Vendor: ProSpec-Tany
$60.00 USD
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Safety Data Sheet
UniProt Listing
NCBI Link

Product Details

Product Description

Recombinant Human Tyrosine Kinase ErbB-3 is a protein that belongs to the ErbB family of receptor tyrosine kinases. This family plays a vital role in cellular signaling pathways, particularly in regulating cell growth and differentiation. With a molecular weight of approximately X kDa, Recombinant Human Tyrosine Kinase ErbB-3 is involved in various physiological processes, including embryogenesis and tissue development. Understanding the function and regulation of this protein has significant implications in cancer research and therapeutic interventions.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System E. coli
Purity 95% by SDS-PAGE
Activity
 Measured by its ability to postpone tumor emerge time of spontaneous breast cancer in FVB/N transgenic mice and inhibit the development of tumor, effectively inhibit the growth of in situ transplanted breast cancer in FVB/N transgenic mice. Measured by its ability to postpone tumor emerge time of spontaneous breast cancer in FVB/N transgenic mice and inhibit the development of tumor, effectively inhibit the growth of in situ transplanted breast cancer in FVB/N transgenic mice.
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 N/A
Structure Dimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Frozen
Formulation Each mg protein contains 1 mg aluminum hydroxide 10mM arginine, 10mM sodium chloride, 20mM sodium phosphate buffer and 5mM potassium phosphate.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

Check Uniprot Link

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution
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References

Not Available
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ErbB3
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