ErbB2

Alternative Names: NEU, NGL, TKR1, HER2, HER-2, c-erb B2, HER-2/neu, Receptor tyrosine-protein kinase erbB-2, EC 2.7.10.1, p185erbB2, C-erbB-2, NEU proto-oncogene, Tyrosine kinase-type cell surface receptor HER2, MLN 19, CD340 antigen.

HER-2/neu is a gene that codes for an orphan receptor tyrosine kinase known as erbB-2. This receptor is always active and forms dimers, and excessive expression can lead to cancer. A transcript of HER-2 called herstatin, which contains intron 8, has been identified. herstatin mRNA is found in normal fetal kidney and liver, but at lower levels compared to p185HER-2 mRNA in carcinoma cells with an amplified HER-2 gene. herstatin appears to inhibit p185HER-2 by disrupting dimers, reducing tyrosine phosphorylation, and inhibiting the growth of transformed cells that overexpress HER-2 independently of anchorage.

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  • Sku: PSB-pka-343-5µg
  • Vendor: ProSpec-Tany
$60.00 USD
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Safety Data Sheet
UniProt Listing
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Product Details

Product Description

Recombinant Human Tyrosine Kinase ErbB-2, also known as HER2/neu, is a member of the epidermal growth factor receptor (EGFR) family. This protein plays a significant role in cell growth and division, primarily in breast and ovarian tissues. With a molecular weight of approximately 185 kDa, HER2/neu is involved in various cellular processes, including signal transduction and regulation of cell proliferation. Understanding the functional characteristics and molecular properties of Recombinant Human Tyrosine Kinase ErbB-2 contributes to the exploration of targeted therapies for cancer treatment.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System E. coli
Purity 95% by SDS-PAGE
Activity
 Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 N/A
Structure Homodimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Frozen
Formulation The ErbB-2 filtered (0.4µm) solution in 0.05M Acetate buffer pH-4 and 5% trehalose.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MTQVCTGTDM KLRLPASPET HLDMLRHLYQ GCQVVQGNLE LTYLPTNASL SFLQDIQEVQ GYVLIAHNQV RQVPLQRLRI VRGTQLFEDN YALAVLDNGD PLNNTTPVTG ASPGGLRELQ LRSLTEILKG GVLIQRNPQL CYQDTILWKD IFHKNNQLAL TLIDTNRSRA CHPCSPMCKG SRCWGESSED CQSLTRTVCA GGCARCKGPL PTDCCHEQCA AGCTGPKHSD CLACLHFNHS GICELHCPAL VTYNTDTFES MPNPEGRYTF GASCVTACPY NYLSTDVGSC TLVCPLHNQE VTAEDGTQRC EKCSKPCARG THSLPPRPAA VPVPLRMQPG PAHPVLSFLR PSWDLVSAFY SLPLAPLSPT SVPISPVSVG RGPDPDAHVA VDLSRYEG.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution
​

References

Not Available
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ErbB2
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