EPOR, Active

Alternative Names: EPO-R, EPOR, Erythropoietin Receptor

The erythropoietin receptor (EPOR) is responsible for mediating the effects of erythropoietin on erythroblast proliferation and differentiation. Upon binding of erythropoietin, EPOR activates the Jak2 tyrosine kinase, which triggers various intracellular pathways such as Ras/MAP kinase, phosphatidylinositol 3-kinase, and STAT transcription factors. EPOR plays a role in promoting erythroid cell survival. Mutations in EPOR may lead to conditions like erythroleukemia and familial erythrocytosis, while dysregulation of EPOR can impact the growth of certain tumors.

  •
  • Sku: PSB-cyt-997-2µg
  • Vendor: ProSpec-Tany
$60.00 USD
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Safety Data Sheet
UniProt Listing
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Product Details

Product Description

Recombinant Human Erythropoietin Receptor, Active is a protein belonging to the cytokine receptor family. It plays a significant role in erythropoiesis by binding to erythropoietin and initiating signaling cascades that promote red blood cell production. This receptor has a molecular weight of approximately 66 kDa and is crucial for the regulation of erythropoiesis in the body.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System Sf9 - Baculovirus cells
Purity 95% by SDS-PAGE
Activity
 Measured by its ability to inhibit EPO dependent proliferation assay using TF-1 human erythroleukemic cells. The ED50 for this effect less or equal to 70ng/ml.
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 25.6 kDa
Structure Dimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Frozen
Formulation EPOR protein solution (0.5mg/ml) contains Phosphate Buffered Saline (pH 7.4) and 10% glycerol.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

APPPNLPDPK FESKAALLAA RGPEELLCFT ERLEDLVCFW EEAASAGVGP GNYSFSYQLE DEPWKLCRLH QAPTARGAVR FWCSLPTADT SSFVPLELRV TAASGAPRYH RVIHINEVVL LDAPVGLVAR LADESGHVVL RWLPPPETPM TSHIRYEVDV SAGNGAGSVQ RVEILEGRTE CVLSNLRGRT RYTFAVRARM AEPSFGGFWS AWSEPVSLLT PSDLDPHHHH HH.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution
​

References

Not Available
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EPOR, Active
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