EPHA2

Alternative Names: ECK, EC 2.7.10.1, EC 2.7.10, EPHA2, EphA2, EPH Receptor A2, Tyrosine-Protein Kinase Receptor ECK, CTRCT6, ARCC2, CTPP1, CTPA, Epithelial Cell Receptor Protein Tyrosine Kinase, Ephrin Type-A Receptor 2, Soluble EPHA2 Variant 1, Epithelial Cell Kinase.

EPHA2 is a protein-tyrosine kinase that belongs to the ephrin receptor subfamily. It plays a role in various developmental processes, particularly in the nervous system. EPHA2 receptors have a specific structure consisting of a single kinase domain, an extracellular region with a Cys-rich domain, and 2 fibronectin type III repeats. The ephrin receptors can be divided into two groups based on their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Mutations in the EPHA2 gene are associated with certain genetically-related cataract disorders.

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  • Sku: PSB-pro-2032-2µg
  • Vendor: ProSpec-Tany
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Safety Data Sheet
UniProt Listing
NCBI Link

Product Details

Product Description

Recombinant Human EPH Receptor A2, also known as EphA2, is a transmembrane receptor protein that belongs to the Eph receptor family. This family of proteins plays a critical role in various cellular processes, including cell adhesion, migration, and axon guidance. EphA2 has a molecular weight of approximately 130 kDa and is expressed in various tissues, including the brain, lung, and kidney. Understanding the function and regulation of EphA2 is of great interest in the scientific community due to its involvement in cancer progression and metastasis.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System HEK 293
Purity 95% by SDS-PAGE
Activity
 Not Available
Activity Assay
Animal Component Free (ACF) No
Molecular Weight
 56.9 kDa
Structure Dimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Lyophilized
Formulation EPHA2 was filtered (0.4µm) and lyophilized from 0.5mg/ml solution in phosphate buffered saline and 5% (w/v) trehalose.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

AQGKEVVLLD FAAAGGELGW LTHPYGKGWD LMQNIMNDMP IYMYSVCNVM SGDQDNWLRT NWVYRGEAER IFIELKFTVR DCNSFPGGAS SCKETFNLYY AESDLDYGTN FQKRLFTKID TIAPDEITVS SDFEARHVKL NVEERSVGPL TRKGFYLAFQ DIGACVALLS VRVYYKKCPE LLQGLAHFPE TIAGSDAPSL ATVAGTCVDH AVVPPGGEEP RMHCAVDGEW LVPIGQCLCQ AGYEKVEDAC QACSPGFFKF EASESPCLEC PEHTLPSPEG ATSCECEEGF FRAPQDPASM PCTRPPSAPH YLTAVGMGAK VELRWTPPQD SGGREDIVYS VTCEQCWPES GECGPCEASV RYSEPPHGLT RTSVTVSDLE PHMNYTFTVE ARNGVSGLVT SRSFRTASVS INQTEPPKVR LEGRSTTSLS VSWSIPPPQQ SRVWKYEVTY RKKGDSNSYN VRRTEGFSVT LDDLAPDTTY LVQVQALTQE GQGAGSKVHE FQTLSPEKLH HHHHH.

Storage Instruction

Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C. Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C.

Sample Prep Instruction

It is recommended to add deionized water to prepare a working stock solution of approximately 0.5 mg/ml and let the lyophilized pellet dissolve completely. EPHA2 is not sterile! Please filter the product by an appropriate sterile filter before using it in the cell culture.

References

Not Available
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EPHA2
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